0.03%他克莫司软膏治疗儿童特应性皮炎的疗效观察及生活质量评价  

A clinical trial of 0.03% tacrolimus ointment in the treatment of atopic dermatitis in children and the investigation of DLQI

作　　者：魏明辉[1] 余碧娥[1] 陈连军[1] 朱敏[1] 杨勤萍[1] 傅雯雯[1] 郑志忠[1] 

机构地区：[1]复旦大学华山医院皮肤科,上海200040

出　　处：《临床皮肤科杂志》2005年第8期547-549,共3页Journal of Clinical Dermatology

摘　　要：目的:评价0.03%他克莫司软膏治疗儿童特应性皮炎的疗效和安全性。方法:采用随机、双盲、平行对照方法,分别对两组儿童特应性皮炎患者外用0.03%他克莫司软膏和赋形剂,疗程为3周。每周对患儿进行随访观察,并在治疗前、后对5～17岁患者作皮肤病学生活质量指数(DLQI)问卷调查。结果:0.03%他克莫司软膏组和对照组的有效率分别为85.0%和33.3%,两组疗效比较差异有非常显著性(P<0.001)。问卷调查表明患者治疗后生活质量明显改善。结论:0.03%他克莫司软膏治疗儿童特应性皮炎安全、有效,治疗后患者的生活质量明显改善。Objective: To evaluate the efficacy and safety of 0.03% tacrolimus ointment in the treatment of atopic dermati-tis in children. Methods: Forty- two children with atopic dermatitis were treated with 0.03% tacrolimus ointment or vehiclefor 3 weeks in a randomized, double- blind, parallel- controlled trial. Efficacy was evaluated and children’s dermatology lifequality index (DLQI) was investigated before and after the therapy. Results: Tacrolimus (0.03%) ointment was significantlymore effective than the vehicle in the children with atopic dermatitis. The patients used 0.03% tacrolimus ointment demon-strated the DLQI was improved. Conclusions: The results showed that 0.03% tacrolimus ointment in the treatment of atopicdermatitis in children was effective and safe, after treatment the quality of life of the patients is improved.

关 键 词：皮炎 特应性 儿童 他克莫司 皮肤病学生活质量指数调查 

分 类 号：R758.2[医药卫生—皮肤病学与性病学]