唾液过氧化物酶体系、溶菌酶、S-IgA与中医脾胃证关系的研究  

Research on the relation between salivary peroxidase system lysozyme S-IgA and spleen-stomach syndrome TCM on the chronic gastric diseases

作　　者：胡彩钦 刘晋生[1] 易崇勤[1] 李桂兰[1] 王立[1] 李颖辰[1] 王丽华[1] 

机构地区：[1]北京市中医研究所,北京市中医医院

出　　处：《中国中西医结合脾胃杂志》1995年第4期195-200,共6页

摘　　要：唾液中含有多种抗微生物因子，根据中医“脾开窍于口”和“涎为脾液”的论述，对慢性胃病患者按胃病类型及中医证型分组．测定唾液过氧化物酶（ＳＰＯ）活性、硫氰酸盐（ＳＣＮ－）、Ｓ－ＩｇＡ和溶菌酶的浓度，作为机体抗菌防御功能的指标，探讨与中医证型的关系。发现：唾液ＳＰＯ活性于脾虚者显著降低，胃阴不足者显著升高，Ｓ－ＩｇＡ于胃阴不足者亦显著升高，而各胃病类型间的的变化不及中医证型的差异显著，提示唾液ＳＰＯ、Ｓ－ＩｇＡ可作为脾虚证及胃阴虚证的客观诊断指标。唾液ＳＣＮ－浓度与吸烟有密切相关。酸刺激可提高ＳＰＯ但不能提高ＳＣＮ－浓度，提示唾液中ＳＰＯ与ＳＣＮ－的来源及分泌机理不同。Salivary contains antimicrobial factors,they form a line of defense to resist bacteria and virus, preventing injury from human's bodies. According to the TCM theory of 'Saliva originates from the spleen'. We determined SPO activity, concentrations of S-IgA and lysozyme muramide in saliva of 177 caces with chronic superficial gestritis or peptic ulcer patients. The results show that SPO activity and S-IgA concentration are significantly increased in the parients with Stomach-Yin deficiecy and significantly desrease in the spleen deficiency. It also suggest diference of syndromes of TCM os more markedly than type of diseases. It is proposed as diagnostic index for spleen deficiency and Stomach-Yin deficiency.The lower pH in patients with Stomach-Yin defciency precented slightly inbalance in acid base metabolism. The SCN- concentration are considerablely high in the patients with wetnessevilsagnating middle warmer,it indecated SCN- concentration have closely relation with smoking.Acid stimulation can markedly elevated SPO activity but SCN- can not. This result suggestedthey are defferent in source and secreted mechanism

关 键 词：唾液 过氧化物酶 次硫氰酸盐 脾胃虚证 SPO 

分 类 号：R256.3[医药卫生—中医内科学]