复方四参饮对病毒性心肌炎患者细胞免疫功能的影响  

Effect of Fu-Fang Si-Shen Yin on Cellular Immunity in Patients with Viral Myocarditis

作　　者：魏强华[1] 郑秀春[1] 石蕴玉[1] 沈博生[1] 傅亚萌 孙瑾[1] 张镜人[1] 

机构地区：[1]上海市第一人民医院中医科

出　　处：《中国中西医结合杂志》1995年第3期144-146,共3页Chinese Journal of Integrated Traditional and Western Medicine

摘　　要：为了研究复方四参饮对病毒性心肌炎患者细胞免疫功能的影响，测定了６０例患者的自然杀伤细胞（ＮＫ细胞）活性和２０例患者的Ｔ淋巴细胞亚群。结果除了ＯＫＴ_８外都显著低于正常值（Ｐ＜０．０１）。经复方四参饮治疗后，除ＯＫＴ_８外皆有显著升高（Ｐ＜０．０５）。中医辩证分型表明，ＮＫ细胞功能下降以气阴两虚组为明显，而Ｔ细胞亚群的改变以气虚组为显著。ＮＫ细胞活性与ＯＫＴ_４／ＯＫＴ_８值呈负相关（Ｐ＜０．０５）。此外，早期ＮＫ细胞功能状况与疾病预后关系密切。In order to study the effect of the Fu-Fang Si-Shen Yin (FFSSY) on cellular immunity, the natural killer (NK) cell activity of 60 patients with viral myocarditis, while the lymphocyte subsets consisted of OKT_3, OKT_4, OKT_8,OKT_4/OKT_8 of other 20 patients were determined.The pretreatmental results were 25.25±10.46%, 59. 11±8.72%, 30.72±6.94%, 29.72±5.35% and 1. 04±0 . 24 respectively, which were significantly lower than that of the normal value (P<0. 01)except OKT_8. However,after the treatment with FFSSY, NK cell activity and OKT_3, OKT_4, OKT_4/OKT_8 were elevated to 30. 96±10. 13% (P< 0. 05) , 62. 33± 7. 78% (P< 0. 05) , 33. 67±5. 50% (P<0. 05) and 1. 14±0 . 20 (P< 0. 01) respectively. The Syndrome Differentiation of TCM indicated that NK cell activity decreased obviously in the Qi-Yin-Deficiency group, while T lymphocyte subsets changed significantly in the Qi-Deficiency group. There existed negative correlation between NK cell activity and OKT_4/OKT_8 (r=-0 . 60, P<0 . 05). The patients with high NK cell activity in the early stage could have a favourable prognosis, while unfavourable with low NK cell activity.

关 键 词：复方四参饮 病毒 心肌炎 自然杀伤细胞 

分 类 号：R259.422.2[医药卫生—中西医结合] R289.5[医药卫生—中医内科学]