不同产地叶下珠及其联合用药抗鸭乙型肝炎病毒的实验研究  

Experimental Study on Anti-Duck Hepatitis B Viral Effect of Phyllanthus urinaria of Different Areas and Combined Therapy with Other Drugs

作　　者：陈压西[1] 郭树华[1] 张定凤[1] 陈学华[1] 

机构地区：[1]重庆医科大学病毒性肝炎研究所

出　　处：《中国中西医结合杂志》1995年第4期225-227,共3页Chinese Journal of Integrated Traditional and Western Medicine

摘　　要：本文应用重庆麻鸭乙型肝炎动物模型进行了不同产地中草药叶下珠及其联合中药苦参及抗菌药环丙沙星的抗鸭乙型肝炎病毒（ｄｕｃｋｈｅｐａｔｉｔｉｓＢＶｉｒｕｓ，ＤＨＢＶ）疗效初探，连续用药１个月后，结果表明：广西叶下珠、云南叶下珠能使鸭血清中鸭乙型肝炎病毒脱氧核糖核酸（ＤＨＢＶＤＮＡ）滴度下降（Ｐ＜０．０５），而重庆叶下珠无此作用（ｐ＞０．０５）；云南叶下珠停药后有血清ＤＨＢＶＤＮＡ回升现象；广西叶下珠与苦参合用，无明显协同作用，但与环丙沙星合用，似有增强抗病毒的作用（Ｐ＜０．０５）。The duck hepatitis B virus model was treated with phyllanthus urinaria of different area and combined with Sopliora flavesceus as well as ciprofloxacin once a day for one month, the results indicated:Guangxi and Yunnan Phyllanthus could lower the serum DHBV DNA significantly(P<0.05),but Chongqing Phyllanthus couldn't.And the amount of serum DHBV DNA rose a week after stopping of Yunnan Phylianthus.The antiviral effect of Guangxi Phyllanthus combined with ciprofloxacin seems to be strengthened(P<0.05).

关 键 词：叶下珠 动物模型 乙型肝炎 环丙沙星 治疗 

分 类 号：R512.620.5[医药卫生—内科学]