妊高征患者胎盘血红素氧合酶-1与血浆内源性一氧化碳变化的研究  

Studies on the Expression of Heme Oxygenase-1 of Placenta and the Level of Plasma Endogenous Carbon Monoxide in Patients with Pregnancy Induced Hypertension

作　　者：韦德华[1] 廖予妹[2] 耿正惠[2] 卢爱妮 

机构地区：[1]河南省濮阳市人民医院,河南濮阳457000 [2]郑州大学第二临床医院,河南郑州450014

出　　处：《实用妇产科杂志》2005年第7期431-433,i001,共4页Journal of Practical Obstetrics and Gynecology

基　　金：河南省自然科学基金资助课题(项目编号:0111022100)

摘　　要：目的:探讨血红素氧合酶内源性一氧化碳(HO-CO)系统与妊娠高血压综合征(简称妊高征)发生、发展的关系。方法:采用免疫组化和联二亚硫酸盐法分别测定了61例妊高征患者及20例正常晚孕妇女胎盘HO1表达强度与血浆CO水平变化。结果:中、重度妊高征组HO1表达强度与血浆CO水平均较正常晚孕组显著降低(P<0.05),各组血浆CO水平与胎盘HO1表达强度间呈显著正相关。结论:胎盘产生的CO可能是妊娠期血浆CO的重要来源之一。Objective: To evaluate the role of HO-CO system in the pathophisiological changes of PIH. Methods We examined the expression of HO in placenta and plasma level of CO in 61 patients with PIH and 20 normal late pregnant women by immunohistochemstry and Chalmers's Dithionate. Results:① HO-1 protein was present predominantly in syncytiotrophoblastic cells and some stem villous endothelium. The intensity of HO-1 immunostaining in syncytiotrophoblast and vascular endothelium was significantly reduced in PIH group when compared with the normal controls, especially in moderate and severe PIH groups. There was negative correlation between the intensity of HO-1 immunostaining and the extent of PIH.② Compared with normal women, plasma CO level in PIH group decreased with advanced degree of PIH, especially in moderate and severe PIH groups. ③ Of four groups, there was a significant positive correlation between level of plasma CO and expression of placental HO-1.Conclusions: CO that produced by placental HO-1 may be the main source of plasma CO. HO-CO system may be one of the factors in the pathogenesis of PIH.

关 键 词：妊娠高血压综合征 血红素氧合酶-1 内源性一氧化碳 

分 类 号：R714.24[医药卫生—妇产科学]