利多卡因超声雾化吸入给药药代动力学研究  

Pharmacokinetics of lidocaine by nebulised inhalation in general anesthesia patients

作　　者：方卫平[1] 李元海[1] 金涌[2] 邓小强[1] 吴蓉蓉[1] 

机构地区：[1]安徽医科大学第一附属医院麻醉科,合肥市230022 [2]安徽医科大学药理研究所

出　　处：《临床麻醉学杂志》2005年第7期442-444,共3页Journal of Clinical Anesthesiology

基　　金：安徽省教育厅2000年资助项目(2000JL263ZC)

摘　　要：目的研究利多卡因经超声雾化吸入给药的药代动力学。方法12例择期全麻病人,随机分为两组,分别吸入利多卡因100mg(Ⅰ组)、200mg(Ⅱ组),不同时间点静脉取血,采用高效液相色谱技术测定利多卡因的血药浓度,用药代动力学计算程序(3p87)处理。结果利多卡因雾化吸入后血药浓度随着雾化吸入剂量的增加而增加,两组峰值浓度(Cmax)分别为(311.5±51.3)和(639.8±9.9)ng/ml;达峰浓度时间(Tpeak)分别为(0.22±0.04)和(0.31±0.06)h,半衰期(T1/2Ke)分别为(0.73±0.07)和(0.74±0.08)h。结论利多卡因雾化吸入的药代动力学符合一级吸收的一房室模型。Objective To study the pharmacokinetics of lidocaine by nebulised inhalation in general anesthesia patients.Methods Twelve patients under general anesthesia were randomly divided into two groups, inhalating lidocaine 100mg (group Ⅰ) and 200mg (group Ⅱ).Blood concentrations of lidocaine were detected by high performance liquid chromatography (HPLC). Data were analyzed by 3p87 program. Results Serum concentration of lidocaine increased as the inhaled dose increased. The main pharmacokenetic parameters of lidocaine following nebulised inhalation in group Ⅰ and Ⅱ were Cmax (311.5±51.3) and (639.8±9.9)ng/ml,Tpeak (0.22±0.04) and (0.31±0.06)h, T_(1/2Ke )(0.73±0.07) and (0.74±0.08)h respectively.Conclusion The concentration-time curve of (lidocaine) by nebulised inhalation is accordant with one-compartmental model of the first-order absorption.

关 键 词：利多卡因 超声雾化 吸入给药 药代动力学 雾化吸入 药物浓度 

分 类 号：R96[医药卫生—药理学]