潘生丁增强抗肿瘤药物作用的体外实验研究  

Potentiation of Anticancer Agent' s Activity in vitro by Dipyridamole

作　　者：杨俊兰[1] 石廷章[1] 魏秀芳[1] 

机构地区：[1]解放军总医院肿瘤内科

出　　处：《中国肿瘤临床》1995年第11期811-813,共3页Chinese Journal of Clinical Oncology

摘　　要：为观察潘生丁与临床常用抗肿瘤药物阿霉素（ＡＤＭ）、长春新碱（ＶＣＲ）及足叶乙甙（ＶＰ－１６）联合应用的价值，我们选用人肺癌细胞株Ａ５４９进行体外细胞毒试验。可以看到：当阿霉素浓度为０．５μｇ／ｍｌ时，对Ａ５４９的抑制率为２９．７６％，加入０．５～１０μｇ／ｍｌ潘生丁时，其细胞生长抑制率提高了１３．２７％～３１．４２％，对长春新碱、足叶乙甙来说，当加入不同浓度潘生丁（０．５～１０μｇ／ｍｌ）时，其细胞生长抑制率分别提高了１８．４３％～４３．２１％及１６．１３％～２９．４７％。以上试验结果表明：潘生丁具有增强某些抗肿瘤药物（ＡＤＭ、ＶＰ－１６、ＶＣＲ）对肺癌细胞株Ａ５４９的细胞毒作用。In order to investigate the value of dipyridamole (DP) When used in combination with the chemotherapeutic agents,we tested the cytotoxic activity of three chemotherapeutic agents (ADM,VP-16,VCR) against lung carcinoma cell line:A549.The result showed:cytotoxicity of ADM at the concentration of 0.5μg/ml against A549 cell line was 29.76%.When adding 0.5-10μg/ml DP,the cytotoxicity increased by 13. 27-31.42%.For VCR and VP-16,when adding 0.5-10μg/ml DP,the cytotoxicity increased by 18.43%-43. 21% and 16. 13%-29.47% respectively.These results suggested that the combination of DP and ADM,VP-16,VCR is potentially useful in cancer chemotherapy.

关 键 词：细胞株A549 抗肿瘤 哌醇啶 肺肿瘤 抗肿瘤作用 

分 类 号：R965.1[医药卫生—药理学] R979.1[医药卫生—药学]