冬虫夏草抗角膜移植排斥反应实验研究的初步报告  

Experimental study on antirejection of cordyceps in penetrating keratoplasty of heterograft

作　　者：李贵仁[1] 万修华[1] 吴强[1] 尤毓陆[1] 张少斌[1] 祝寿荣[1] 藏萍[1] 

机构地区：[1]潍坊医学院附属医院眼科,潍坊医学院免疫学教研室

出　　处：《中国中医眼科杂志》1995年第2期70-73,共4页China Journal of Chinese Ophthalmology

基　　金：山东省中医药管理局科研基金

摘　　要：用兔心脏血Ｔ淋巴细胞转化实验、角膜厚度计和扫描电镜等方法，对鸡→兔穿透性异种角膜移植的实验模型进行检测观察。结果：术后３周时，各组Ｔ淋巴细胞转化率均达峰值，冬虫夏草治疗组心脏血Ｔ淋巴细胞转化率为乃．６９±１．２７，空白对照组为２７．３２±２．３８，组间比较差异存在显著性（Ｐ＜０．０５）；在观察期内，冬虫夏草组植片透明率为６２．５％，而对照组植片出现明显排斥反应，植片透明率为零，植片厚度随混浊程度的加重而增加；电镜下观察冬虫夏草组的Ｄｅｓｃｅｍｅｔ膜内皮细胞优于对照组。结果提示：冬虫夏草在角膜移植术后能发挥免疫抑制剂的作用，并能强化激素的效果。Experimental model on chiken-rabbit penetrating keratoplasty of heterograft wasdetected by means of tranfomation of T-lymph cell of rabbit heart blood.retinal thicknessmearsurement and scanning electron-microscope(SEM).Three weeks after the surgeries the T-lymph cell transition rates of both the test group and the control group increased to the peak of15.69 ± 1.27 and 27.32 ± 2.38 respectively.The difference between two groups was remarkable(P< 0.05).uring the observation. the transparency of the implant the cordyceps group was62.5%in contrast to the zero transparency of the implant ofthe control group. in which obviousrejection existed and the thickness of the implant increased with the increasing opacity.SEMshown the endothelialial cells in Descemet membrane were suprior over those ofthe control group. The results showed that cordyceps could played a role as an immunity inhibitor and hormone en-hancer.

关 键 词：冬虫夏草 角膜移植 排斥反应 异种移植 

分 类 号：R276.796.5[医药卫生—中医五官科学] R282.710.5[医药卫生—中医学]