用血清药理学方法研究中药苦参、仙鹤草的抗肿瘤作用  

STUDY ON ANTITUMOR ACTIVITY OF THE SOPHORA FLAVESCENS AIT AND AGRIMONIA PRLOSA LEDEB BY METHOD OF SERUM PHAMACLOLGY

作　　者：王力倩[1] 余上才[1] 李仪奎[1] 李悦 

机构地区：[1]上海中医药大学新药药理毒理研究中心,上海200032

出　　处：《中国中医药科技》1995年第5期19-21,共3页Chinese Journal of Traditional Medical Science and Technology

摘　　要：采用中药血清药理学研究方法进行离体试验,观察含苦参、仙鹤草的血清及其煎剂对肿瘤细胞体外生长的影响。结果发现苦参、仙鹤草煎剂及含苦参血清均有明显的抗肿瘤活性,而含仙鹤草血清则无效。初步证明苦参对肿瘤细胞体外生长确实有一定的细胞毒作用,而含仙鹤草血清及其煎剂出现不同实验结果的原因,可能与中药粗制剂干扰因素有关,也可能受药物在体内代谢过程及血清等因素的影响。paper studies the antitumor activity of the serum with Sophora FLavescents Ait (SFA)and Agrimonia pilosa Ledeb(APL)by mean of the method of Serum pharmacology. The results showed that the serum with SFA (s - sFA)could obviously inhibit the proliferation of Sigo and EAC cells in vitro ,the S-SFA could inhibit EAC cells'growth by 50. 2%, and the serum with APLCS -APDwas by 9. 9% with the anti - staining method,with the MTT assay,it was found that when S -SFA was added and with S180 and EAC cells for 3 days, the percentage of cytotoxicyty was 27. 78% and 34. 58% respctively,but the S-APL has no effect on S180 or EAC cells. These experiments suggest that SFA has significant antitumor activity.

关 键 词：中药血清药理学 苦参 仙鹤草 药理学 肿瘤 

分 类 号：R282.710.5[医药卫生—中药学] R273.05[医药卫生—中医学]