羟氨苄青霉素和奥美拉唑联合治疗幽门螺杆菌感染的初步研究  

The Study of Treatment Helicobacter Pylori of Stomach Cancer with Amoxycillin and Omeprazole in a Population in the High-Risk Region in China

作　　者：赵雷[1] 江骥 张联[1] 刘伟东[1] 马峻岭[1] 张劲松[1] 昌云生[1] 金懋林[1] 徐光炜[1] 游伟程[1] 

机构地区：[1]北京医科大学临床肿瘤学院,北京市肿瘤防治研究所,北京协和医院,山东省临朐县卫生局,山东省潍坊市医药研究所

出　　处：《中国肿瘤临床》1995年第12期837-840,共4页Chinese Journal of Clinical Oncology

摘　　要：在胃癌高发区山东省临朐县，对一组血清幽门螺杆菌抗体及￣１３Ｃ尿素酶呼吸试验阳性的自然人群共９３人，用羟氨苄青霉素和奥美拉唑进行了为期２周的幽门螺杆菌治疗研究，并分别在服药前、停药后及停药后３个月，用￣１３Ｃ尿素酶呼吸试验做为检测指标，观察其清除率和根除率。结果显示，按时服药和漏服１次组清除率和根除率均较高，合并清除率为７７．９％，根除率为６８．３％。漏服１天者清除率和根除率明显下降。拒服和退出组无１例清陈。本研究结果表明，羟氨苄青霉素和奥美拉唑联合用药对幽门螺杆菌感染有良好治疗效果，且药效与服药依从性关系密切。为治疗幽门螺杆菌感染，特别是在人群中进行干预试验，以减少胃癌和胃癌前病变的发生提供了依据。Abstract In the past few years some evidence for helicobacter pylori as a potential cause of stomach cancer has been accumulated in a village in county Linqu,Shan Dong province,where incidence rate of stomach cancer is higher in the world.70% of the population aged 40 to 70.To evaluate the efficacy of therapy in combination with an acid pump inhibitor and antibiotics,a two-week trial with omeprazole(20mg b.i.d)and amoxycillin (lg b.i.d)was conducted in 97 subjects with positive ￣13 C-urea breath test (￣13 C-UBT)to helicobactet Pylori in the village. The efficacy was assessed by the ￣13 C-UBT.The clearance rate after treatment and eradication rate after a duration of 3 moths in 72 patients who completed the two-week course were 76.5% and 68.3%,respectively.The efficacy was significantly reduced

关 键 词：幽门螺杆菌 羟氨苄青霉素 奥美拉唑 药物疗法 

分 类 号：R516.05[医药卫生—内科学] R978.11[医药卫生—临床医学]