冠心病患者白细胞膜黏附分子CD_(11b)/CD_(18)表达的研究  

Expression of Adhesion Molecules CD_ (11b)/CD_ (18) on Leucocytes in Patients With Coronary Heart Disease

作　　者：王雄[1] 刘胜辉[1] 贾永平[1] 窦岩[2] 李运乾[1] 

机构地区：[1]山西医科大学第一医院心内科,山西省太原市030001 [2]山西医科大学中心实验室

出　　处：《中国循环杂志》2005年第3期183-185,共3页Chinese Circulation Journal

摘　　要：目的:探讨冠心病患者中性粒细胞和单核细胞膜黏附分子CD11b/CD18的表达。方法:对60例冠心病患者(冠心病组)采用流式细胞仪直接免疫荧光法与20例正常者(正常组)比较检测中性粒细胞和单核细胞膜黏附分子CD11b/CD18的表达。结果:冠心病组中性粒细胞和单核细胞膜黏附分子CD11b/CD18表达较正常组均增加,有显著性差异(P<0.05),环磷酸腺苷葡胺对不稳定性心绞痛患者干预后,其表达显著增高,有极显著性差异(P<0.01)。结论:冠心病患者中性粒细胞和单核细胞膜黏附分子CD11b/CD18表达明显增加,其增加程度与心肌缺血的类型有关。Objective:To investigate the expression of adhesion molecules CD_ 11b/CD_ 18 on neutrophils and monocytes in patients with different type of coronary heart disease (CHD),and to study the effects of meglumine adenosine cyclophosphate on their expression. Methods: The expression of CD_ 11b/CD_ 18 on neutrophils and monocytes were measured by flow cytometry -direct immunofluorescence techniques in 60 patients with CHD . Results: Expressions of CD_ 11b/CD_ 18 on neutrophils and monocytes in the CHD patients were markedly higher than those in normal cases(p<0.05),expressions of CD_ 11b/CD_ 18 markedly increased in patients with unstable angina pectoris in the presence of meglumine adenosine cyclophosphate. Conclusion: Neutrophil and monocyte CD_ 11b/CD_ 18 adhesion molecules in patients with CHD had a higher expression, the degree of increased expression might be related to the types of myocardial ischemia.

关 键 词：冠心病 流式细胞仪 CD11B/CD18 

分 类 号：R541.4[医药卫生—心血管疾病]