前S_1蛋白对乙型肝炎临床诊断作用的研究  

APPLICATION STUDY OF THE HBV PRES_1 IN HEPATITIS B DIAGNOSIS

作　　者：张宏伟 加永泽培 高明东 

机构地区：[1]西藏自治区昌都地区人民医院

出　　处：《西藏医药》2005年第3期6-8,共3页Tibetan Medicine

摘　　要：目的检测HBV感染者PreS1并与乙肝血清标志物进行比较,进一步探讨PreS1在乙肝临床诊断中的作用。方法应用ELISA方法测定225例HBV感染者PreS1及乙肝血清标志物。结果高复制组(HBsAg、HBeAg、HBcAb三项阳性)的PreS1阳性率为852%;低复制组(HBsAg、HBeAg、HBcAb三项阳性)的PreS1阳性率为487%,两组差异显著。PreS1与HBeAg具有一致性,但HBeAg阴性感染者中存在36%的PreS1阳性。急性乙肝患者、慢性乙肝患者及无症状病毒携带者的PreS1阳性率分别为957%、487%和146%。PreS1阳性和阴性患者的转氨酶水平(ALT和AST)差异显著。结论PreS1做为一种新的HBV感染、复制和乙肝诊断、治疗以及预后的标志物具有很大的应用价值。Objective To evaluate the effect of PreS_1 in the clinical diagnosis of hepatitis B patients by measuring the level of PreS_1 and comparing with the markers in serum of hepatitis B. Methods serum PreS_1AG and markers of hepatitis B of 225 patients of hepatitis B were detected by ELLISA method.Results the positive rate of PreS_1 in high duplication group were 85.20% and 48.7% in low group,there was significant difference consistent with the HBeAg.The positive rate in HBeAg(+) was 36%,however.The positive rates in acute,chronic patients and carrier having no symptom were 95.7%,48.7%,14.6% respectively.There was significant difference of the ALT and AST levels between the two groups of PreS_1(+) and PreS_1(-).Conclusion PreS_1,as a new marker of hepatitis in acute HBV infection,duplication patients,has a great applying value in hepatitis B diagnosis,treatment and prognosis.

关 键 词：前S1蛋白 诊断作用 乙型肝炎 乙肝血清标志物 PRES1 HBV感染者 ELISA方法 HBeAg阴性 HBCAB 慢性乙肝患者 差异显著 病毒携带者 转氨酶水平 阳性率 临床诊断 阴性患者 应用价值 复制 一致性 无症状 

分 类 号：R512.62[医药卫生—内科学] R587.2[医药卫生—临床医学]