肺腺泡内动脉构形重建与肺动脉高压等的关系  

The relationship of intraacinar pulmonary arterial structural remodelling with pulmonary hypertension

作　　者：吴永平[1] 车东媛[1] 张婉蓉[1] 李文英[1] 

机构地区：[1]武汉同济医科大学病理学教研室,江苏徐州医学院病理学教研室

出　　处：《中华病理学杂志》1995年第2期86-89,共4页Chinese Journal of Pathology

基　　金：国家"八五"攻关课题

摘　　要：以野百合碱一次性皮下注射复制大鼠肺动脉高压和肺心病模型。应用光镜、电镜、免疫组织化学和形态定量等方法，观察了肺腺泡内动脉不同病变在肺动脉高压中的作用。结果表明了肺循环功能与结构之间的关系，反映出肺腺泡内动脉构形重建是肺动脉高压形成的病理学基础。结果提示肺腺泡内动脉壁周细胞的增生和肌样分化，对无肌型肺动脉的肌化意义重大。Pulmonary hypertension(PHT)was induced in rats by a single subcutaneous injection of monocro-taline (MCT).Light and electron microscopy,immunohistochemistry and morphometry were applied to investigate the different pathological changes of the intraacinar pulmonary arteries(IAPA) and their re-lationship with PHT. The results showed that pulmonary function was related to the morphoIogical structure and indicated that the remodelling in the IAPA structure was the pathological basis of PHT.The results further suggested that the proliferation and myoid differentiation of the pericyte play an im-portant role in the muscularization of the nonmuscular pulmonary artery in IAPA.

关 键 词：肺心病 高血压 肺性 肺动脉 动物模型 

分 类 号：R541.502[医药卫生—心血管疾病] R363.21[医药卫生—内科学]