异基因外周血干细胞移植术后中毒性表皮松解症临床分析  

Clinical Analysis of Toxic Epidermal Necrolysis After Allogenic Peripheral Blood Stem Cell Transplantation

作　　者：寿黎红[1] 黄河[1] 方红[1] 蔡真[1] 施继敏[1] 张慧英[1] 林茂芳[1] 

机构地区：[1]浙江大学附属第一医院

出　　处：《中国皮肤性病学杂志》2005年第7期409-410,414,共3页The Chinese Journal of Dermatovenereology

摘　　要：目的总结异基因造血干细胞移植后中毒性表皮松解症(TEN)诊治经验。方法分析3例表现为TEN的造血干细胞移植后急性移植物抗宿主病(aGVHD)。结果3例TEN均发生于外周血干细胞移植后,表现为皮肤水疱及表皮松解,合并高热、肠炎或肝损害,经给予有效的免疫抑制剂,联合营养支持及相应护理措施,皮损均消退。结论TEN是皮肤GVHD最严重的类型,需采用针对aGVHD的免疫抑制为主的综合治疗。Objective To conclude the experiences of the diagnosis and treatment of toxic epidermal necrolysis(TEN) after allogenic peripheral blood stem cell transplantation.Methods 3 cases developing acute graft versus host disease after hemopoietic stem cell transplantation were analysed ,whose clinical manifestation was toxic epidermal necrolysis.Results Toxic epidermal necrolysis appeared after peripheral blood stem cell transplantation and showed blister and epidemidolysis,combined with hyperpyrexia,enteritis or hepatic damage.Skin destruction recovered after the usage of effective immunosuppressive agent,associated with nutritional support and skin attendance.Conclusion TEN is a serious type of graft versus host disease.Immunosuppressive methods aimed at acute graft versus host disease is the key of the comprehensive therapy.

关 键 词：外周血干细胞 移植 中毒性表皮松解症 

分 类 号：R758.2[医药卫生—皮肤病学与性病学]