单纯性肾病综合征T细胞白细胞介素2受体水平的研究  被引量:14

STUDIES ON EXPRESSlON OF IL-2R ON TCELLS AND SERUM SIL-2R LEVEL INCHILDREN WITH SIMPLE NEPHROTICSYNDROME

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作  者:张秋业[1] 董增义[1] 杨美玉[1] 孙艾梅 耿新杰[1] 王守亮[1] 

机构地区:[1]青岛医学院附属医院儿科,青岛医学院附属医院检验科,青岛医学院儿科系血液与遗传研究室

出  处:《中华儿科杂志》1995年第2期98-100,共3页Chinese Journal of Pediatrics

摘  要:对35例单纯性肾病综合征(SNS)患儿T细胞白细胞介素2受体(IL-2R)和血清可溶性白细胞介素2受体(sIL-2R)水平等进行检测。结果显示,活动期患儿自然状态和植物血凝素活化后T细胞IL-2R表达率皆明显低于缓解期和正常对照组,而SIL-2R水平却明显增高;活动期患儿T细胞IL-2R自然表达率与血清SIL-2R水平和细胞数呈负相关,而与细胞数和细胞比值呈正相关,活动期患儿血清SIL-2R水平与细胞数、细胞比值和血清IgG水平呈负相关,而与细胞数呈正相关。提示活动期患儿T细胞免疫应答能力低下,T细胞IL-2R表达受抑和血清SIL-2R水平增高,与SNS患儿T细胞亚群和功能紊乱及低IgG血症关系密切。he expression rates of interleukinz receptor (IL-ZR) on T cells and serum soluble interleukin-2 receptor(SILZRi level were determined in 35 children withsimple nephrotic syndrome (SNSI. The results indicated that (li compared with remission stage of SNS andcontrol group , the expression rates of ILZR on T cellsat both natural status and activated status with PHA atacute stage of SNS were all decreased and the serumSIL-ZR level were increased; (2i the expression ratesof ILZR on T cells at natural status at caute stage ofSNS had negative correlations with the concentrationsof serum SIL-ZR and the number of CDs+ cells, butpositive correlations with the number of CD.+ cells andthe ratio of CD.+ICDs+ cells; ( 3i the serum SIL-ZRlevel had negative correlations with the number of CD`+cells, the ratio of CD.+jCDs+ cells, and the level ofserum IgG , but a positive correlation with the numberof CDs+ cells. These results suggested that (ll at theacute stage of SNS the immune respnse ability of Tcells decreased ; t2) lower expression rates of ILZR onT cells and higher serum SILZR level were closely related to the abnormal T cells subsets and Tcell func-tions and to the decreased level of serum IgG in patientswith SNS.

关 键 词:儿童 肾病综合征 白细胞介素2 T细胞 亚群 受体 

分 类 号:R726.920.3[医药卫生—儿科] R692.03[医药卫生—临床医学]

 

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