慢性肝炎患者血浆vWF及其前肽与纤溶系统测定的临床意义  

Clinical significance of detection of plasma von Willebrand factor, von Willebrand factor propeptide and plasminogen system in chronic hepatitis patients

作　　者：韩纪举[1] 魏然[1] 李震[2] 任道凌[1] 吴亚平[1] 王增贤[1] 陈彬[1] 

机构地区：[1]泰山医学院基础医学研究所 [2]泰安市中心医院检验科,山东泰安271000

出　　处：《第四军医大学学报》2005年第14期1289-1292,共4页Journal of the Fourth Military Medical University

摘　　要：目的:探讨肝炎患者血浆vWFpp,vWF,tPA,PAI1及DDimer含量及临床意义.方法:利用ELISA法对肝炎组及对照组血浆vWFpp,vWF,tPA,PAI1及DDimer含量进行测定.结果:肝炎组血浆vWFpp(1.54±1.83)mg/L与对照组(0.43±0.09)mg/L有显著差异,P<0.01;vWF(60.30±99.81)mg/L与对照组(11.27±5.34)mg/L有显著差异(P<0.01);tPA(27.87±14.05)μg/L与对照组(16.70±7.13)μg/L有显著差异(P<0.01);PAI1(43.22±13.53)μg/L与对照组(63.37±6.63)μg/L有显著差异(P<0.01);DDimer(1.02±1.36)mg/L含量与对照组(0.60±0.67)mg/L有显著差异(P<0.01).vWFpp含量与vWF,DDime间具有显著的相关性(P<0.01);tPA含量与PAI1含量间亦具有显著的相关性(P<0.05).其他测定项间无显著的相关性.结论:慢性肝炎患者的血液vWFpp,vWF,D二聚体、tPA及PAI1水平能通过不同途径反映肝病时机体的凝血与纤溶系统的状态,且对于病情的判断和预后具有重要意义.AIM: To investigate the plasma level of Willebrand factor propeptide (vWF-pp), Willebrand factor (vWF), tPA, PAI-1 and D-Dimer in hepatitis patients and to evaluate their clinical significance. METHODS: The levels of vWF-pp, vWF, tPA, PAI-1 and D-Dimer in hepatitis groups and control groups were determined by Sandwich enzyme linked immuno-sorbent assay (ELISA). RESULTS: The levels of vWF-pp were significantly different between hepatitis patients (1.54±1.83) mg/L and control groups (0.43±0.09) mg/L P<0.001. The level of vWF was respectively (60.30±99.81) mg/L and (11.27±5.34 ) mg/L in hepatitis patients and in control, with significant difference (P<0.005). The levels of D-Dimer, PAI-1 and tPA were significantly different between hepatitis patients and control groups (P<0.001, P<0.005). vWF-pp concentration showed significantly positive correlation with blood vWF and D-Dimer levels ( P<0.01). There was obvious correlation between the level of tPA and PAI-1 (P<0.05). CONCLUSION: The plasma level of vWF-pp, vWF, tPA, PAI-1 and D-Dimer in hepatitis patients can reflect vessel wall injury, indicating problems of coagulation and fibrinolysis in vivo. These observations are of important value for both diagnosis and prognosis of the disease.

关 键 词：von WILLEBRAND因子 血管性假血友病因子前肽 组织型纤溶酶原激活物 纤溶酶原激活物抑制物1 D-二聚体 肝炎 慢性 

分 类 号：R446.112[医药卫生—诊断学]