决定细胞形状和运动性的蛋白质palladin  

Palladin is a Key Molecule to Cell Shape and Movement

作　　者：张应玖 [1] YANMIN YANG  

机构地区：[1]吉林大学生命科学学院,分子酶学工程教育部重点实验室,长春,130023,Department of Neurology, Stanford University, Stanford, CA 94305, USA [2]Department of Neurology, Stanford University, Stanford, CA 94305, USA

出　　处：《生物化学与生物物理进展》2005年第7期607-611,共5页Progress In Biochemistry and Biophysics

摘　　要：Palladin是肌动蛋白结合蛋白家族的新成员,广泛分布于平滑肌、中枢神经系统和胚胎的各种组织中,其主要的生物功能是参与构建肌动蛋白骨架系统,并在细胞骨架的动态变化中起作用.在肌动蛋白细胞骨架中palladin与alpha-辅肌动蛋白共存在.目前发现,palladin在决定细胞的形态和迁移或运动等过程中起关键的作用.在转移性癌细胞和中枢神经受损伤后的星形胶质细胞中,都有palladin的特殊表达.Palladin的表达使星形胶质细胞形成了神经胶质疤痕.Palladin is a novel actin-associated protein, its distribution is ubiquitous in smooth muscle, central nervous system and embryonic tissues. It seems that palladin is required for the establishing/maintaining actin cytoskeleton and its dynamic assembly. Palladin colocalizes with alpha-actinin in actin cytoskeleton. Findings show that palladin play a critical role in controlling cell shape, cell migration or movement. Palladin expression is upregulated in metastatic cancer cells and astrocytes following traumatic injury to the central nervous system. Palladin upregulation allows the astrocytes to form the glial scar.

关 键 词：PALLADIN 形状 运动 神经胶质疤痕 

分 类 号：Q245[生物学—细胞生物学]