孕妇血清耐热性碱性磷酸酶放射免疫测定的临床应用  

Clinical application of radioimmunoassay serum heat-stable alkaline phosphatase in pregnancy

作　　者：肖为红 曹国宪[1] 俞惠新[1] 李卫一[1] 王成瑜[1] 李金泉[1] 糜祖煌[1] 

机构地区：[1]江苏省原子医学研究所,苏州市妇幼保健院,苏州医学院附属第一医院妇产科,无锡市妇幼保健院

出　　处：《中华妇产科杂志》1995年第2期77-79,共3页Chinese Journal of Obstetrics and Gynecology

基　　金：卫生部青年科学基金

摘　　要：采用耐热性碱性磷酸酶（ＨＳＡＰ）放射免疫测定（ＲＩＡ）方法，对６４９例正常妊娠及１６４例高危妊娠妇女血清进行测定。结果：正常孕妇血清ＨＳＡＰ与孕周呈正相关（相关系数ｒ＝０．９８４３）。好高征、胎儿生长迟缓孕妇血清ＨＳＡＰ明显降低；新生儿窒息及胎儿窘迫孕妇血清ＨＳＡＰ低于同孕周正常孕妇；妊娠合并肝内胆汁瘀积症孕妇与同孕周正常孕妇血清ＨＳＡＰ水平差异不大。表明：此方法对于高危妊娠及胎儿预后的判断具有一定的临床价值。Serum heat-stable alkaline phosphatase( HSAP) level in 649 cases of normal pregnancy and 164 cases of high-risk pregnancy were measured by radioimmunoassay (RIA). The results indicated that the HSAP level increased proportionally with the advance of gestationai age(r=0. 984 3).In33 cases of pregnancy induced hypertention and 21 cases of intrauterine fetal growth retardation,the HSAP were at significantly low level.In 7 cases of neonatal asphyxia and 26 cases of fetal distress. the HSAP Ievel in the mother's erum were also low. In 53 cases of intrahepatic cholestaisi of pregnancy,the HSAP Ievels were similar to those of normal pregnancy.This study illustiated that HSAP RIA can play an important role in the evaluation of placental function and fetal proknosis for casp:of high-risk pregnancy.

关 键 词：碱性磷酸酶类 放射免疫测定 血清 孕妇 预后 

分 类 号：R715.3[医药卫生—妇产科学]