化疗药物导致恶性滋养细胞肿瘤患者心脏毒性反应六例临床分析  

Clinical analysis of 6 cases of gestational trophoblastic neoplasms complicated by cardiotoxicity after chemotherapies

作　　者：吴燕[1] 钱和年[1] 

机构地区：[1]北京医科大学人民医院妇科

出　　处：《中华妇产科杂志》1995年第6期366-368,共3页Chinese Journal of Obstetrics and Gynecology

摘　　要：我院自１９９３年３月～１２月共收治６例妊娠滋养细胞恶性肿瘤患者，均行大剂量５－氟脲嘧啶和更生霉素联合化疗，共２１人次，１０人次（４７．６％）出现了化疗后心脏毒性反应。其中４人次出现心悸、胸闷及（或）心前区疼痛；２例（２人次）出现心力衰竭；７人次（７０．０％）有心电图改变，５人次（５０．０％）有血清谷草转氨酶升高。经治疗９人次（９０．０％）症状缓解，心电图及血清谷草转氨酶恢复正常，１例死亡。提示：化疗中应重视患者主诉，严密监测心电图及血清酶变化。estational trophoblastic neoplasm treated by large dosage of 5-fluorouracil and actinomycin could cause cardiotoxicity.In 6 cases of gestational trophoblastic neoplasms admitted to our hospital from March to December 1993,cardiotoxicity was found to have occurred after chemotherapies in 10/21 courses.There were 2 cases with heart failures,4 cases with palpitation and 4 cases with feelings of op-pression and(or)chest pains. In 7 cases the electrocardiogram(EKG)findings were abnormal(70.0%)and in 5 cases there were increased sera glutamic oxalacetic transaminase enzyme(AST).90.0% of these complications were brought under control after decreasing the dosages and changing the methods of administration. If the proper managements were not given on time,patient may even ex-pire. So attention should be paid to this complication. It is suggested that attention should be paid to pa-tients’ subjective symptoms, and proper surveillance by EKG and serum AST determinations should be conducted to minimize deaths due to chemotherapeutic complications.

关 键 词：滋养层肿瘤 药物疗法 心脏疾病 并发症 子宫肿瘤 

分 类 号：R541[医药卫生—心血管疾病] R737.330.5[医药卫生—内科学]