卵泡发育类型和黄体功能关系的探讨  

Different Patterns of Follicular Development and Luteal Function

作　　者：顾玲芬[1] 张丽珠[1] 顾方颖[1] 耿力[1] 王泽密[1] 

机构地区：[1]北京医科大学第三临床医学院妇产科

出　　处：《中华妇产科杂志》1995年第9期539-542,共4页Chinese Journal of Obstetrics and Gynecology

摘　　要：应用阴道Ｂ超连续监测不孕症患者７６例，其中正常单卵泡排卵者４８例（单卵泡组），正常双卵泡排卵者５例（双卵泡组），小卵泡排卵者１４例（小卵泡组），多囊卵巢（ＰＣＯ）排卵者３例（ＰＣＯ组），卵泡不破裂黄素化综合征（ＬＵＦＳ）排卵者６例（ＬＵＦＳ组）。结果：单卵泡组子宫内膜发育迟缓２例，黄体期过短５例，黄体功能不全（ＬＰＤ）的发生率为１４．５８％；双卵泡组黄体功能均正常；小卵泡组子宫内膜发育迟缓３例，黄体期过短５例，ＬＰＤ发生率为５７．１４％；ＰＣＯ组子宫内膜发育迟缓１例，黄体期过短１例；ＬＵＦＳ组无子宫内膜发育迟缓，黄体期过短３例。后３种类型的ＬＰＤ的总发生率为５６．５２％，与正常卵泡比较，差异有极显著性（Ｐ＜０．００５）。提示：黄体功能与卵泡发育类型密切相关。bjective To study the relationship between luteal function and different patterns of follicular development.Methods Different patterns of follicular development as observed under transvaginal B-ultra-sound in 85 infertile patients included:(1) Ovulation from normal follicle (ONF).(2) Ovulation from two follicles at the same cycle(O2F).(3) Ovulation from small follicle(OSF).(4) Ovulation from polycystic ovaries(PCO).(5)Luteinized unruptured follicle syndrome (LUFS).(6) Anovula-tion with follicular atresia, The luteal function of the first 5 types was evaluated by serum and peri-toneal fluid estrogen,progesterone levels, endometrial histology, Estradiol receptor(ER)and pro-gesterone receptor(PR ) analyses,and the length of luteal phase.Results The incidence of luteal phase deficiency(LPD):short luteal phase was 10. 42%,retar-dation of endometrial development was 4.17%in ONF, no LPD in O2F,21.42%in OSF,2/3 in PCO,3/6 in LUFS,respectively, The incidence of LPD was 14.58%in ONF,56.52%in abnormal follicular development groups(OSF,O2F and LUFS)(P<0.005).It was found that the retardation of endometrial development was associated either with lowered serum P level or normal serum P but lowered ER and PR concentrations.The latter condition was recognized as“pseudocorpus luteum de-ficiency”。Couclusions The different patterns of follicular development may exert a great influence over luteal function through the different production of steroid hormones and their receptors。

关 键 词：卵泡 雌激素 孕酮 黄体退化 

分 类 号：R339.22[医药卫生—人体生理学]