正常人髂嵴活检标本的骨组织形态计量学分析  

Histomorphometric Analysis of The Iliac Crest In160 Normal Biopsy Series

作　　者：郭昭庆[1] 党耕町[1] 王志国[1] 张克立[1] 蔡钦林[1] 张潭澄[1] 娄思权[1] 

机构地区：[1]北京医科大学第三医院骨科

出　　处：《中华骨科杂志》1995年第4期228-231,共4页Chinese Journal of Orthopaedics

摘　　要：对１９８４～１９９０年采集的１６０例（男１２７，女３３）正常人骼嵴标本进行骨组织形态计量学分析。结果表明，骨小梁相对体积ＴＢＶ（％）在３０岁以后男、女性均随年龄增长而下降（Ｐ＜０．０５）。女性ＴＢＶ（％）在６０岁以前明显高于同年龄组的男性（Ｐ＜０．０５）。男、女性骨小梁平均骨壁厚度ＭＷＴ（μｍ）在３０岁以后也均随年龄增长而下降（Ｐ＜０。０１）。女性骨小粱类骨质表面Ｓｏｓ（％）在６０岁以前随年龄增长渐升（Ｐ＜０．０５）。男性Ｓｏｓ（％）及吸收表面Ｓｒ（％）虽在各年龄组间无显著性差异，但在５０岁以后可见一上升趋势。类骨质相对体积ＲＴＯＶ（％）无显著性别及年龄间差异。本组结果提示，男、女性随着年龄老化均产生了一定量的骨丢失，而其丢失的组织学机制可能与重建负平衡及骨转换率增高有关。AbstractBone spounens from 160 normal individuals(male,127,female,33) were obtained with biopsy at the iliaccrest. Undecalcified bone sections were produced and his-tomorphometric analysis were performed.The resultsshowed that,after age of 30 the trabecular bone volume( TBV%)decreased significantly with increasing age (P<0.05)and correlated to age(P<0.01).A significantdifference was found between males and females.Themean wall thickness of packets(MWT)also decreasedsignificantly with increasing age (P<0.01).but no sexdifference was observed.The osteoid surface(Sos%) andthe resorption surface(Sr%)increased before 60’s andthen decreased in female (p<0.05),however,in male,increased slightly after 50’s,despite the difference wasnot significant, The relative trabecular cateoid volume(RTOV%)was found to be age-independent and sex-in-dependent .Our results suggested that bone loss occurredwith increasing age in both males and females,and it’spossibile histological mechanism may be the bone remod-elling imbalance and the high bone turnover.

关 键 词：髂嵴 骨组织 形态计量学 活检 诊断 

分 类 号：R323.1[医药卫生—人体解剖和组织胚胎学]