长期尾部悬吊大鼠心肌超微结构的变化(英文)  

Ultrastructural changes of myocardium in long-term tail-suspended rats

作　　者：陈杰[1] 张立藩[1] 马进[1] 刘健[1] 

机构地区：[1]第四军医大学航空航天生理学教研室,西安710032

出　　处：《中华航空医学杂志》1995年第3期133-137,共5页

基　　金：国家自然科学基金!39170795

摘　　要：观察了尾部悬吊40d和120d大鼠心肌超微结构的变化。结果显示，40d悬吊大鼠心肌细胞浆内糖原增加；心肌毛细血管内皮细胞生成了许多凸出物伸向管腔内。这些改变与空间实验室及宇宙号生物卫星搭载航天大鼠心肌超微结构变化基本一致，而与以往在地面用应激程度严重的“禁动”模型所观察的变化有所不同。此外，我们还发现120d悬吊大鼠心肌细胞内脂褐素增加，这在以往航天及地面模拟研究中均未见报道，可能是长期失重或模拟失重下心肌超微结构变化的重要特点之一。上述形态学改变可归结为两方面的问题，即心肌糖酵解过程受到抑制和心肌组织的降解过程增强。从而支持长期模拟失重大鼠的心脏处于低动力状态的假说。The myocardial ultrastructural responses to simulated microgravity were investigated in rats subjected to tail-suspension for 40 or 120 days. Ultrastructural changes observed in the myocardium of tail-suspended animals included intra- and extra-mitochondrial glycogen accumulation, and extensive capillary endothelial projections. These morphological alterations are qualitatively similar to those of the rats carried by biosatellites. In addition, a storage of lipofuscin was found in the myocardial cells in 120- day tail-suspended animals. The results suggest a depressed glycolysis and an enhanced degradation in the myocardium and supported the hypothesis that the heart during long-term simu1ated microgravity was in a hypodynamic state.

关 键 词：模拟失重 心肌 超微结构 动物实验 

分 类 号：R852.220.2[医药卫生—航空、航天与航海医学]