^（131）I去除分化好的甲状腺癌术后残留甲状腺组织的评价  

The ablation of residual thyroid tissue by ￣(131)I following surgery for thyroid cancer

作　　者：匡安仁[1] 管昌田[1] 于南[1] 谭天秩[1] 

机构地区：[1]华西医科大学附属一院核医学科

出　　处：《中华核医学杂志》1995年第1期29-31,共3页Chinese Journal of Nuclear Medicine

摘　　要：用１３１Ｉ去除１０５例分化好的甲状腺癌（ＤＴＣ）术后残留甲状腺组织，去除剂量为２．２２～５．５５ＧＢｑ．以２４小时甲状腺吸１３１Ｉ率＜１％和１１１～１８５ＭＢｑ１３１Ｉ显像甲状腺不显影为完全去除的标准．２．２２～２．９６ＧＢｑ组一次去除率为６３．３％，３．７０～５．５５ＧＢｑ组为８５．３％，总一次去除率为７９．１％．本研究结果表明．女性、去除剂量大、术后残留甲状腺组织少和无甲状腺外功能性转移灶者的去除率较高，反之则较低．去除率与病理类型和年龄无关．建议对所有ＤＴＣ术后患者均常规进行１３１Ｉ去除治疗，去除剂量以３．７０～５．５５ＧＢｑ为宜．Abstract patients with well differentiated thyroid cancer received an initial dose of 2.22～5.55GBq of ￣(131)I for ablation of thyroid remnants after surgery. Criteria for successful ￣(131)I ablation were the absence of ￣(131)I uptake in the neck (24h ￣(131)I uptake <1%) and the disappearance of thyroid tissue image after using 111～185 MBq ￣(131)I.The results showed that in patients receiving doses of 2.22～2.96MBq and 3.70～5.55 GBq,the efficacy of ablation was 63.3% and 85.3% respectively and there was no serious side effects following ￣(131)I administration.Female patients required higher doses of ￣(131)I and the presence of less amount of residual thyroid tissue or absence of functioning metastatic disease gave better results.Age and histopathology did not have any influence on the efficacy of ablation.The authors suggest that ablation must be performed in any patients in whom obvious accumulation of ￣(131)I activity in the thyroid bed is observed postopcratively and the dose of 3.70～5.55GBq of ￣(131)I is appropriate.

关 键 词：碘 投药 剂量 甲状腺肿瘤 癌 放射疗法 

分 类 号：R817.8[医药卫生—影像医学与核医学] R736.105[医药卫生—放射医学]