Graves甲亢^（131）I治疗后早发甲低  

The early development of hypothyroidism after ￣(131)I treatment for hyperthyroid Graves' disease

作　　者：康增寿[1] 周前[1] 刘世贞[1] 

机构地区：[1]北京协和医院核医学科

出　　处：《中华核医学杂志》1995年第1期26-28,共3页Chinese Journal of Nuclear Medicine

摘　　要：８２７例Ｇｒａｖｅｓ甲亢１３１Ｉ治疗病人门诊随访一年以上已愈．每次随访作体检及甲状腺机能生化指标ＴＴ３、ＴＴ４和ＴＳＨ测定．９０％早发甲低发生在１３１Ｉ治疗后２～３个月内，此时应认真随访．ＴＴ４是诊断１３１Ｉ治疗后甲低的灵敏指标．而ＴＴ３诊断甲低价值不大，ＴＳＨ在诊断１３１Ｉ治疗后甲低不如ＴＴ４灵敏．早发甲低的发生与１３１Ｉ剂量密切相关，如何计算剂量使其既治愈甲亢又不发生永久性甲低是我们工作的目标．Abstract patients with Graves' hyperthyroidism following ￣(131)I treatment were followed up at 3 monthly intervals for 12～36 months from 1985 to 1991.Physical examination and serum total T_3, T_4,TSH measurements were made at each visit.According to our present data,90% early hypothyroidism occured within 2～3 months after ￣(131)I treatment,thereby,careful follow-up study is very important during this period.T_4 was much more sensitive than T_3 in diagnosing early hypothyroidism,while the TSH level shows thyroid reservation function,and is less sensitive than T_4 in diagnosing ￣(131)I induced hypothyroidism.Our study confirmed the view that the early incidence of post ￣(131)I therapy hypothyroidism was strongly dose dependent

关 键 词：甲状腺肿 放射疗法 碘 甲状腺机能减退 副作用 

分 类 号：R817.8[医药卫生—影像医学与核医学] R581.105[医药卫生—放射医学]