^（99m）Tc－MIBI心肌断层显像定量分析心肌血流灌注和存活的研究  

Study on myocardial blood flow perfusion and viability with ￣(99m)Tc-MIBI tomography imaging

作　　者：陈宪英[1] 裴著果[1] 王凯庚[1] 张兆忠[1] 钟希德[1] 李杰芬[1] 刘志凡[1] 

机构地区：[1]沈阳军区总医院核医学科,中国医科大学第二临床学院核医学科

出　　处：《中华核医学杂志》1995年第1期16-18,共3页Chinese Journal of Nuclear Medicine

摘　　要：制成１２只狗冠状动脉（ＣＡ）左前降支（ＬＡＤ）人工狭窄（结扎）模型．测定其ＣＡ不同血流量与９９ｍＴｃ－甲氧基异丁基异腈（ＭＩＢＩ）摄取率的相关性．早期静态研究结果表明，９９ｍＴｃ－ＭＩＢＩ摄取率与血流量呈正相关（ｒ＝０．９４６），晚期结果显示缺损区范围较早期缩小，９９ｍＴｃ－ＭＩＢＩ摄取率增加（Ｐ＜０．０１）．部分存活的心肌细胞基本恢复正常，并可见纤维组织包绕的心肌“细胞岛”．测定９９ｍＴｃ－ＭＩＢＩ摄取率可定量地评估患者病情，指导治疗，判断疗效和预后．Abstract dog models of the artificial coronary artery stenosis (ligation) in varying degrees were quantitatively analysed with ￣(99m)Tc-MIBI SPECT myocardial imaging and by measuring regional myocardium uptake rate.Correlation was studied between blood flow in varying degrees and ￣(99m)Tc-MIBI uptake rate with the purpose of relating myocardial blood perfusion to viability. Early measuring results showed that ￣(99m)Tc-MIBI uptake rate and blood flow of the coronary artery have a good positive correlation (r=0.946).Delayed results showed that the volume of defect was reduced and ￣(99m)Tc-MIBI uptake rate was increased (P<0.01).The partially viable myocardium cells have recovered normally and showed myocardial cell island encircled by fibrous tissue. Measuring ￣(99m)Tc-MIBI uptake rate may be used to assess patients'condition,direct treatment and follow up the effect of treatment.

关 键 词：心脏 放射性核素显像 血液供给 动物实验 诊断 

分 类 号：R817.42[医药卫生—影像医学与核医学]