门控^（99m）Tc－MIBI心肌灌注断层显像测量室壁收缩分数的方法学研究  

METHODOLOGY OF MEASURING WALL CONTRACTION FRACTION WITH GATED ￣(99m)Tc-MIBI MYOCARDIAL TOMOGRAPHY

作　　者：曾骏[1] 赵惠扬[1] 王凤琴[1] 黄钢[1] 陈可靖[1] 单越芬[1] 

机构地区：[1]上海医科大学中山医院校医学研究室

出　　处：《中华核医学杂志》1995年第3期142-144,共3页Chinese Journal of Nuclear Medicine

摘　　要：建立门控９９ｍＴｃ-甲氧基异丁基异腈心肌灌注断层显像的定量分析方法．方法：计算室壁收缩分数（ＷＣＦ）和功能低下面积（ＤＦＡ），直接反映心脏整体和局部的心肌收缩功能，并以ＷＣＦ功能曲线及其靶心图显示．结果：ＷＣＦ和ＤＦＡ的测定重复性很好，ＣＶ分别为３．３０％和３．６％．ＷＣＦ、几何法测量的ＥＦ和ＤＦＡ呈负相关（ｒ分别为-０．８５６３和-０．８３９０）．门控心肌断层显像法与心室显像计数法测量的ＥＦ值相关性好（ｒ＝０．８９０７）．正常人、冠心病和心肌梗塞患者的ＷＣＦ值分别为０．４３８±０．０３０、０．３０６±０．０８１和０．２８９±０．０９５．左前降支、右冠状动脉、左冠状动脉回族支和多支冠状动脉分布区灌注低下患者的ＷＣＦ值分别为０．２８１±０．０７７、０．３１９±０．０７１、０．３０３±０．０６６和０．２４８±０．１０６．前三者之间差异无显著性（Ｐ＞０．０５），但后者低于前三者（Ｐ＜０．０５）．平衡心室显像测量ＥＦ值、门控心肌显像测量ＥＦ值和ＷＣＦ值对冠心病的诊断灵敏度分别为７２．４％、４８．３％和８２．８％．结论：门控心肌断层显像测量ＷＣＦ值、ＷＣＦ功能曲线及其靶心图能全面客观地评价心脏收缩功能．PURPOSE To develop a method for quantitating wall contraction fraction (WCF) by gated 99mTc-MIBI myocardial tomography. METHODS The WCF profile and its polar map were displayed from the end systolic (ES) and the end diastolic (ED) profile. The WCF values were calculated from WCF profile. RESULTS The precision of measuring WCF was very good, the CY value being 3.3%. The corresponding correlation coefficients (r) of the global and regional myocardial contraction function were as follows: WCF and dysfunction areas (DFA), r = -0.8563; ejechon fraction (EF)and DFA, r=so.8390. In normals, WCF was 0.438± 0.030 (x ± s); in patients with coronary artety diseases (CAD)and myocafdial infarctions (MI), WCF was 0.306 ± 0.081 and 0.289± 0.095 respectively, both CAD and MI WCF values being less than normals (P < 0.001). Sensitivity of EF for CAD from gated myocardial tomographic and gated blood pool studies was 48.3% and 72.4%, but sensitivity of WCF was 82.8%. CONCLUSIONS The WCF values and its profile can be used for the assessment of global and regional LV wall contraction, while the size and position of dysfunction can be assessed by WCF polar map.

关 键 词：心肌 心放射图描绘 锝99M MIBI 收缩分数 方法学 

分 类 号：R817.42[医药卫生—影像医学与核医学]