血脂的海拔性变化对高脂血性动脉超微结构损伤的影响  

The effect of altitude changes of blood lipid on hyperlipemic ultrastructural damage in aorta and coronary arteries

作　　者：李侠[1] 张鑫生[1] 齐文斌[1] 王建国[1] 魏国庆[1] 孙宏夫[1] 

机构地区：[1]青海省人民医院老年病研究所

出　　处：《中华老年医学杂志》1995年第4期224-227,共4页Chinese Journal of Geriatrics

基　　金：国家人事部留学回国人员科研基金;卫生部1990年度科技经费;青海省卫生厅资助

摘　　要：我们对低、中和高海拔（江苏省南京市市中心区２０ｍ、青海省西宁市２２６１ｍ和青海省天峻县３８００ｍ）实验家兔血脂、超氧化物歧化酶（ＳＯＤ）和丙二醛（ＭＤＡ）的动态观察表明：ＨＤＬ－Ｃ、ＨＤＬ３－Ｃ和ＳＯＤ随海拔升高而上升（Ｐ＜０．０５及０．０１）；ＴＣ、ＴＧ、ＨＤＬ３－Ｃ和ＭＤＡ则下降（Ｐ＜０．０５及０．０１）。采用光镜、扫描和透射电镜观察了不同海拔自然环境对高脂血性主动脉和冠状动脉损伤的影响，结果显示，随着海拔的升高动脉粥样硬化的发生率降低，病变程度减轻，并对其可能的机理进行了初步探讨。Abstract Dynamic observations on blood lipid,superoxide dismutase(SOD) and malondialdehyde(MDA) of experimental rabbits at different altitudes(20m,2261m and 3800m) showed that the levels of HDL-C,HDL3-C and SOD were elevated significantly with increasing altitudes,but levels of TC,TG,MDA and HDL2-C were on the contrary. Study on hyperlipemic damage of aortae and coronary arteries at different altitudes by light microscope,scanning and transmission microscope indicated that incidence of atherosclerosis and degree of lesion were decreased with increasing altitudes.The possible mechanism of altitude intervention on hyperlipemia was discussed.

关 键 词：海拔 动脉粥样硬化 超微结构 高血脂病 

分 类 号：R589.202[医药卫生—内分泌]