含1H-吡唑和咪唑的新型双杂环化合物的合成与生物活性  

Synthesis and Biological Activities of Novel Bis-heterocyclic Compounds Containing 1H-pyrazole and Imidazole

作　　者：谭成侠[1] 沈德隆[1] 王成 刘会君[1] 翁建全[1] 欧晓明 

机构地区：[1]浙江工业大学农药研究所,浙江杭州310032 [2]湖北沙隆达股份有限公司,湖北荆洲434001 [3]国家南方农药创制中心湖南基地生测部,湖南长沙410007

出　　处：《合成化学》2005年第4期372-374,383,共4页Chinese Journal of Synthetic Chemistry

基　　金：浙江省教育厅资助项目(20030145)

摘　　要：1-甲基-3-乙基-4-取代-5-吡唑甲酰氯与含氮杂环反应,合成了8个新型结构的双杂环化合物。其结构经1HNMR,IR,MS和元素分析表征。初步生物活性实验结果表明:在500μg·mL-1,部分化合物对稻黑尾叶蝉的抑制活性达到53.57%。Eight novel pyrazolyl-heterocycles were synthesized from 1-methyl-3-ethyl-4-substituted-5-pyrazolecarboxylic chloride and nitrogen heterocyclic rings. Their structures were confirmed by (~1H NMR,) IR, MS and elementary analysis. The preliminary biological test showed that some compounds, at 500 μg·mL^(-1), exhibited inhibitory activities(53. 57%) against Nephotettix cincticeps.

关 键 词：吡唑 咪唑 苯并咪唑 合成 生物活性 

分 类 号：O626.21[理学—有机化学]