吸入皮质激素对哮喘患者血清嗜酸粒细胞和T－淋巴细胞功能的影响  

Effect of inhaled corticosteroids on serum ECP andsIL-2R levels in asthmatics.

作　　者：王杭君[1] 孙滨[1] 

机构地区：[1]第四军医大学西京医院

出　　处：《中华结核和呼吸杂志》1995年第5期306-308,共3页Chinese Journal of Tuberculosis and Respiratory Diseases

摘　　要：为研究吸入皮质激素倍氯米松对哮喘患合体内嗜酸粒细胞、Ｔ－淋巴细胞功能状态的影响，对治疗前后哮喘患者血清嗜酸性阳离子蛋白（ＥＣＰ）、可溶性白细胞介素－２（ｓＩＬ－２Ｒ）浓度及患者乙酰甲胆碱气道反应性进行检测。结果表明。吸入皮质激素６周后，血清ＥＣＰ、ｓＩＬ－２Ｒ浓度降低，肺功能改善、乙酰甲胆碱－ＰＣ＿（２０）（ＦＥＶ＿１下降２０％时的乙酰甲胆碱激发浓度）值增高。提示：糖皮质激索能抑制嗜酸性粒细胞、Ｔ－淋巴细胞激活。具有抗炎和降低气道高反应性的作用。o study the influence of corticosteroid and β_2-ago-nist on cosinophil and T lymphocyte functioning state inthe asthmatics,we measured the serum ECP、sIL-2Rlevels and airway reactivity before and after 6-weektreatment with beclometasone and terbutalin.The re-sult revealed that after inhalation of steroid,the serumECP、sIL-2R levels decreased,whereas the lung functionimproved and MCH-PC_(20)values increased.It suggestedthat steroid could inhibit activation of eosinophil and Tlymphocyte as well as show the effect of anti-inflamma-tion and reducing AHR.

关 键 词：哮喘病 ACTH 吸入疗法 嗜酸粒细胞 T细胞 药理学 

分 类 号：R562.250.5[医药卫生—呼吸系统] R977.11[医药卫生—内科学]