老年人收缩期高血压血浆心钠素改变的研究  

A study on the changes of plasma atrial natriuretic peptide in systolic hypertension in the elderly

作　　者：杜心清[1] 吴景元[1] 郑善德[1] 吴佑星[1] 

机构地区：[1]福建医学院附属第二医院

出　　处：《中华老年医学杂志》1995年第1期15-17,共3页Chinese Journal of Geriatrics

摘　　要：采用放射性免疫分析法测定５２例老年收缩期高血压患者的血浆心钠素（ＰＡＮＰ）水平。结果：老年收缩期高血压患者ＰＡＮＰ水平（１４３９．５±２１１．８ｎｇ／Ｌ）较健康对照组（４９６．１±３２．７ｎｇ／Ｌ）显著增高，且与血压增高幅度呈正相关；在代偿期内靶器官损害越严重，ＰＡＮＰ水平愈高。老年收缩期高血压伴左室肥厚组的ＰＡＮＰ水平（１７９６．８±３２５．２ｎｇ／Ｌ）显著高于无左室肥厚组（８８７．３±１１９．３ｎｇ／Ｌ），我们认为ＰＡＮＰ水平可作为评价老年收缩期高血压患者靶器官损害程度、有无合并左室肥厚的一个参考指标。Abstract Plasma atrial natriuretic peptide(PANP) level was determined by radioimmunoassay in 52 elderly patients with systolic hypertension. The results showed that the average PANP level in elderly Patients with systolic hypertension(1440±212ng/L)was significantly higher than that in the control group(496±33 ng/L).(P<0.01) .The PANP level was positively correlated with mean blood pressure(r=0.61, P<0.05) . The more the target organs were damaged, the more the level of PANP increased. The PANP level in the elderly with systolic hypertension and left ventricular hypertrophy(1797±325 ng/L) was significantly higher than that in the group without left ventricular hypertrophy(887±119 ng/L) (P<0.01) . The PANP level might be of help for the evaluation of damage in the target organ and evaluation of presence of left ventricular hypertrophy.

关 键 词：高血压 血液 心钠素 老年人 

分 类 号：R544.102[医药卫生—心血管疾病]