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作 者:王秋月[1] 张鸿[1] 闫雪[1] 康健[1] 于润江[1]
机构地区:[1]中国医科大学附属第一医院呼吸疾病研究所,沈阳110001
出 处:《中华结核和呼吸杂志》2005年第7期445-447,共3页Chinese Journal of Tuberculosis and Respiratory Diseases
摘 要:目的探讨慢性阻塞性肺疾病(COPD)患者血清抵抗素、瘦素水平及其与营养状况的关系.方法用酶联免疫吸附测定(ELISA)和放射免疫法检测57例稳定期COPD患者和31名健康对照者血清抵抗素、瘦素水平,分析相关因素.结果 COPD患者血清抵抗素、瘦素水平[(2.1±1.2)、(0.65±0.41)μg/L]与对照组[(3.6±2.3)、(1.03±0.71)μg/L]比较差异均有统计学意义(P均<0.01).COPD营养不良患者抵抗素、瘦素水平[(1.7±0.7)、(0.43±0.16)μg/L]显著低于非营养不良患者[(2.2±1.2)、(0.73±0.48) μg/L,P均<0.05].COPD患者抵抗素与瘦素、第一秒用力呼气容积(FEV1)及FEV1/用力肺活量(FVC)显著正相关(r=0.426~0.531, P均<0.01),瘦素与体重指数(BMI)、胸围、腹围、抵抗素及FEV1/FVC显著正相关(r=0.371~0.580, P均<0.01).结论COPD稳定期患者血清抵抗素、瘦素水平下降,合并营养不良时下降更显著.Objective To investigate the serum resistin and leptin levels,their relationship to nutritional state and the associated factors in patients with chronic obstructive pulmonary disease(COPD). Methods The serum resistin and leptin levels in 57 stable COPD patients and 31 healthy controls were measured by enzyme-linked immunosorbent assay(ELISA) and radio-immunoassay respectively. Correlated factors of serum resistin and leptin were analyzed. Results The serum resistin and leptin levels in COPD patients[(2.1±1.2),(0.65±0.41)μg/L] were significantly lower than those in the healthy controls[(3.6±2.3),(1.03±0.71)μg/L,all P<0.01]. The serum resistin and leptin levels in patients with malnutrition[(1.7±0.7),(0.43±0.16)μg/L] were significantly lower than those in patients without malnutrition[(2.2±1.2),(0.73±0.48)μg/L,all P<0.05]. The serum resistin level in the patients was correlated with the serum leptin level,forced expiratory volume in one second(FEV1),and FEV1/forced vital capacity(FVC)(r=0.426-0.531,all P<0.01). The serum leptin level in the patients was correlated with serum resistin,FEV1/FVC,body mass index(BMI),percentage of ideal body weight(IBW%),chest circumference and abdominal circumference(r=0.371-0.580,all P<0.01). Conclusion The serum resistin and leptin levels in stable COPD patients were significantly lower,especially in patients with malnutrition.
关 键 词:血清抵抗素 慢性阻塞性肺疾病患者 瘦素水平 营养状况 慢性阻塞性肺疾病(COPD) COPD患者 酶联免疫吸附测定 FEV1/FVC 营养不良 用力呼气容积 免疫法检测 用力肺活量 体重指数 稳定期 正相关 对照组 统计学 下降
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