硬膜外腔持续输注丁哌卡因一芬太尼混合液用于术后镇痛的研究  

Postoperative analgesic effects after continuous epidural infusion with Bupivacaine-Fentanyl mixture

作　　者：房文学[1] 刘文格 刘秀文[1] 解大建[1] 

机构地区：[1]北京医科大学附属第一医院麻醉科,100034

出　　处：《中华麻醉学杂志》1995年第7期304-306,共3页Chinese Journal of Anesthesiology

摘　　要：观察３０例胸、腹部术后患者４８小时的镇痛效果。随机分为三组：Ｉ组（对照组）接受全身性阿片类药物上痛； Ⅱ、Ⅲ组（观察组）用微量泵硬膜外腔持续输注 ０．１％丁哌卡因和 ０．０００５％芬太尼混合液每小时２ｍｌ、５ｍｌ上痛。用药后观察镇痛效果和对呼吸及循环系统的影响。结果：Ⅱ、Ⅲ组镇痛效果较Ⅰ组为好，其镇痛效果持续、稳定、用药量少（Ｐ＜０．０１）。注药期间三组未发生呼吸抑制及循环的明显改变。Ⅲ组个别病例出现皮肤瘙痒，停药后自动缓解。Thirty patients after thoracic or abdominal operations were randomly divided into three groups. The patients in group I (control group) were given systemic opiates when pain intensity above 3 rd grade occured, The ones in group and received continuous epidural infusion with a mixture of 0' 1 % bupivacaine and 0. 0005% fentanyl at rates of 2ml/h and 5ml/h respectively by a micro infusion pump. The analgesic effects in group and were better and stabler and the drugs dosages used were much less than in control group,with significant differences between either group or and group I (P< O. 01). Pain relief of group m is much more significantly better than group (P< O. 01 ). There were no inhibition of respiratory system and circulatory changes during the procedure in all three groups. Respiratory freguency in group I increased much more than in group N,but the skin'S itching occured in several patients of group and relieved spontaneously following withdrawal of the infusion.

关 键 词：硬膜外腔 微量泵 术后镇痛 丁哌卡因 芬太尼 

分 类 号：R614.42[医药卫生—麻醉学]