阈下剂量氯胺酮与异丙酚并用的临床研究  

Clinical study on the effects of propofol combined with a low-dose ketamine.

作　　者：刘宗民[1] 贺柏林[2] 宋运琴[2] 靳冰[2] 

机构地区：[1]解放军254医院麻醉科,天津市300142 [2]解放军总医院麻醉科

出　　处：《中华麻醉学杂志》1995年第9期420-422,共3页Chinese Journal of Anesthesiology

摘　　要：选择２４例择期下肢手术患者，在硬膜外阻滞及血流动力学稳定的条件下，临床组静注氯胺酮０．５ｍｇ／ｋｇ和异丙酚２．５ｍｇ／ｋｇ，对照组单独静注异丙酚２．５ｍｇ／ｋｇ。做两组间血压、心率、经皮血氧饱和度（ＳｐＯ２）和麻醉苏醒时间的比较。结果表明，氯胺酮 ０．５ｍｇ／ｋｇ能防止由异丙酚引起的血压下降，同时两药的某些副作用明显减轻或消失，但异丙酚的呼吸抑制作用和苏醒时间明显延长。作者认为阈下剂量氯胺酮并用异丙酚用于麻醉诱导和维持，能产生较稳定的血流动力学效果，适宜门诊短小手术。To investigate the changes of the effects of propofol combined with a low-dose ketamine,twenty-four patients,ASA class I, undergoing low extremity operation under epidural anesthesia ,were randomly assigned to intravenously receiving the combination of propofol 2.5mg/kg and ketamine 0. 5mg/kg (group A,n=11) or propofol alone 2. 5mg/kg(group B, n =13 ). The systolic and diastolic arterial pressures (SAP,DAP),HR and SpO2 were continously monitored before and after the administration. The durations of anesthesia and incidences of adverse reactions after awakening were recorded. The results demonstrated that as compared with those in group B,there were less drops in hemodynamic parameters (P<0. 05),the anesthetic duration was significantly pro longed (P<0. 05),the incidence of the adverse reaction markedly decreased but the more drop in SpO2 occured,in group A(P< 0. 05 ). It is indicated that a low-dose ketamine can potentiate the anesthetic effect of propofol,act against its hypotensive effect and adverse reactions,however make its respiratory depression become more.

关 键 词：阈下剂量 氯胺酮 异丙酚 临床研究 

分 类 号：R971.2[医药卫生—药品]