尼卡地平伍用芬太尼减轻气管插管时心血管副反应的研究  

Inhibitory effect of combination of nicardipine and fentanyl on circulatory response to intracheal intubation.

作　　者：曹经山[1] 黄海波[1] 陈华珍[1] 陈明森 汪腊生[1] 

机构地区：[1]湖北医科大学附属一院麻醉科,武汉市430060

出　　处：《中华麻醉学杂志》1995年第11期503-505,共3页Chinese Journal of Anesthesiology

摘　　要：３６例ＡＳＡＩ级择期手术患者，随机分为三组，每组 １２例。全麻诱导均静脉注射硫喷妥钠８ｍｇ／ｋｇ和琥珀胆碱２ｍｇ／ｋｇ。诱导前５分钟组Ⅰ静注生理盐水４ｍｌ，组正静注尼卡地平０．０１ｍｇ／ｋｇ，组Ⅲ静注尼卡地平０．０１ｍｇ／ｋｇ和芬太尼３μｇ／ｋｇ。结果显示组见在插管后ＳＢＰ、ＨＲ、和ＲＰＰ变化最小。表明静注尼卡地平０．０１ｍｇ／ｋｇ和芬太尼３μｇ／ｋｇ是减轻气管插管时心血管副反应的有效方法。This study was undertaken to assess the effects of intravenous nicardipine (NC) combined with fentanyl (FT) on cardiovascular reactions to endotracheal intubation. Thirty-six patients, ASA Class I, aged 20 to 60 years, scheduled for elective operations, were randomly allocated to intravenously receiving normal saline as placebo(group Ⅰ), NC 0. 01 mg/kg (group Ⅱ) or combination of NC 0.01 mg/kg and FT 4μg/kg (group Ⅲ) respectively, at 5 mins before intravenous administrations of thiopenial (TH) and succinylcholine(SUC) during induction of anesthesia. The ECG, SBP, HR and RPP were recorded at various times between the moment before administration and the time at 10th min after intubation. The results demonstrated that the abnormal EEG did not occur in these three groups; after administration of the combination in group Ⅲ, the values of the above parameters kept statistically unchaged (P>0. 05) except for a slight decrease in SBP after injections of TH and SUC before intubation(p<0. 05 ),and increased tansiently following intubation(P<0. 05); as compared with the levels in group l,the above yalues decreased markedly in group aam during induction and following intubation. The HR levels rose remarkablely following administration of NC and intubation in group Ⅱ, which were higher than those in group I (P<0. 05). So we suggest that intravenous NC combined with FT may keep henlodynamics stable to a great degree during induction and intubation,and can be applied safely and effectively to clinical anesthesIa.

关 键 词：尼卡地平 芬太尼 气管插管 心血管反应 

分 类 号：R614[医药卫生—麻醉学]