海洛因依赖者下丘脑－垂体－肾上腺轴功能改变  

THE FUNCTIONAL CHANGES OF HYPOTHALAMUS-PITUITARY-ADRENAL AXIS IN HEROIN ADDICTS

作　　者：李红[1] 杨良[1] 徐仕文[1] 潘常忠[1] 冯文忠[1] 汤保德[1] 张玉祖 刘肃谟 

机构地区：[1]昆明医学院第一附属医院内分泌科,昆明医学院药物依赖性研究治疗中心,昆明市康复治疗所,昆明卷烟厂职工医院

出　　处：《中华内分泌代谢杂志》1995年第2期86-87,共2页Chinese Journal of Endocrinology and Metabolism

基　　金：云南省科学技术委员会青年基金

摘　　要：观察５４例海洛因依赖者和３０例正常人血浆β－卜内啡肽、ＡＣＴＨ和皮质醇水平。结果显示海洛因依赖者上午８时β－内啡肽，ＡＣＴＨ和皮质醇均明显降低，而零时血皮质醇明显高于对照。提示β－内啡肽ＡＣＴＨ和皮质醇可作为评判戒吸治疗效果的指标之一，而且改善下丘脑－垂体－肾上腺轴功能可能有助于戒毒康复过程。The plasma β -endorphin,ACTH and cortisol levels were evaluated in 54 heroin addicts(HA)and 30 controls.The resultslwed that all HA had lower levels of plasma β-endorphin, ACTH and cortisol at 8:00 a.m., but had higher plasma cortisol levelat zero o′colck as compared with the controls. These data indicate thal determination of the plasma β-endorphin,ACTH and cortisollevels can be used as one of the criteria to evaluate the effects of drug refraining treatment.and improvement of the hypothalamus-pituitary-adrenal axis function may be helpful to the convalescencc of the addicts。

关 键 词：海洛因依赖性 Β内啡肽 ACTH 皮质醇 

分 类 号：R992[医药卫生—毒理学]