^（99m）Tc－DTPA肾动态显像测定GFR对糖尿病肾病早期诊断的价值  

ESTIMATION OF GLOMERULAR FIL TRATIONRATE BY^(99m)Tc-DTPA DYNAMIC RENOGRAPHY IN EARLY DIAGNOSIS OF DIABETIC NEPHROPATHY

作　　者：赵淑好[1] 林军[1] 王中心[1] 潘时中[1] 严孙杰[1] 杨立勇[1] 吴立坚[1] 林好学[1] 陈学升[1] 倪达人[1] 

机构地区：[1]福建医学院附属第一医院内分泌科,福建医学院附属第一医院核医学科,福建医学院附属第一医院信息电脑科

出　　处：《中华内分泌代谢杂志》1995年第2期91-93,共3页Chinese Journal of Endocrinology and Metabolism

摘　　要：应用￣（９９ｍ）Ｔｃ－ＤＴＰＡ肾动态显像测定６１例ＮＩＤＤＭ的肾小球滤过率（ＧＦＲ），并与相配对的２０例正常人作比较。结果表明无蛋白尿的糖尿病患者ＧＦＲ，升高率为３５％，且与血糖呈正相关。提示￣（９９ｍ）Ｔｃ－ＤＴＰＡ肾动态显像测定ＧＦＲ可作为糖尿病肾病最早期诊断的检测手段。ＮＩＤＤＭ早期确实存在肾小球高滤状态．ＧＦＲ＞１４０ｍｌ／ｍｉｎ可作为糖尿病肾病发生的预兆指标。Estimation of glomerular filtration rate(GFR)by￣(99m)Tc-DTPA dynamic renography was performed in 61 NIDDM patients and 20 normal control persons,The GFR was calculated according to Gate,s formula. The results showed that GFR was significantly higher in NIDDM patients without proteinuria and the rate of incrcment was35%,with GFR positively correlated with the fasting plasma glucose level. GFR was significantly lower in NIDDM patients withproteinuria and the rate of decrement was 76.2%。 The results indicate that there is a glomerular hyperfiltration state in the earlystage of NIDDM,Estimation of GFR by￣(99m)Tc-DTPA dynamic renography could be a useful procedure in the earliest diagnosis of di-abetic nephropathy. GFR>140ml/min may be used as a predictive inedx of the development of diabetic nephropathy.

关 键 词：糖尿病 糖尿病肾病 放射性核素显像 肾动态 诊断 

分 类 号：R587.106[医药卫生—内分泌] R692.04[医药卫生—内科学]