Ⅱ型糖尿病合并高血压患者高胰岛素血症和舒血管前列腺素关系的探讨  

HYPERINSULINEMIA AND VASODILATOR PROSTAGLANDINS IN TYPE 2 DIABETES MELLITUS PATIENTS WITH HYPERTENSION

作　　者：贾伟平[1] 丁汉伦[1] 戴信刚[1] 毛共存 倪红燕 袁晓红 

机构地区：[1]西安医科大学第二附属医院内分泌科,上海市第六人民医院内分泌科

出　　处：《中华内分泌代谢杂志》1995年第2期98-100,共3页Chinese Journal of Endocrinology and Metabolism

摘　　要：对２３例非胰岛素依赖型糖尿病（ＮＩＤＤＭ）患者、１８例ＮＩＤＤＭ合并高血压的和平共１８例正常人在糖耐量试验期间血胰岛素、６－酮－前列腺素Ｆ＿（１α）（６－ｋｅｔｏ－ＰＧＦ＿（１α）和前列腺素Ｅ＿２（ＰＧＥ＿２）水平进行了测定。ＮＩＤＤＭ并高血压组基值和糖负荷后血清胰岛素水平显著升高，６－ｋｅｔｏ－ＰＧＦ＿（１α）和ＰＧＥ＿（２）浓度显著下降，尤以胰岛素释放高峰为明显。胰岛素与６－Ｋｅｔｏ－ＰＧＦ＿（１α）浓度呈显著负相关。提示ＮＩＤＤＭ合并高血压可能与高胰岛素血症抑制舒血管前列腺素合成有关。The serum insulin and placma 6-keto-PGF_(1α) and PGE_2 were measured in 18 non-insulin -dependent diabetes mellitus (NIDDM)patients with hypertension,23 normotensive NIDDM patients and 18 controls. The fasting and stimulated serum insulin levels weremarkedly increased (P<0.01),while the basic and stimulated plasma 6-keto-PGF-(1α) and PGE_2 levels were significantly reduced(P<0.01)during oral glucose tolerance test(OGTT) in the hypertensive NIDDM patients. The plasma 6-keto-PGF_(1α) response duringOGTT was inversely correlated with significance(r=0.57.P<0.05)to the elevated insulin level in the hypertensive NIDDMgroup.The results suggest that the inhibition of,synthesis of prostaglandins by hyperinsulinemia may play an important role in the increase of blood pressure in the diabetic patients with hyportension .

关 键 词：糖尿病 高血压 前列腺素 并发症 高胰岛素血症 

分 类 号：R587.106[医药卫生—内分泌] R544.102[医药卫生—内科学]