肠道物理通透性在强直性脊柱炎发病中的作用  

THE ROLE OF INTESTINAL PERMEABILITY IN THE PATHOGESIS OF ANKYLOSING SPONDYLITIS

作　　者：刘毅[1] 徐秉玖[1] 蔡醒华[1] 张驰[1] 

机构地区：[1]第一军医大学中西医结合研究所风湿病专科,北京医科大学分析化学教研室,解放军总医院风湿科

出　　处：《中华内科杂志》1995年第2期91-94,共4页Chinese Journal of Internal Medicine

摘　　要：选用低分子量聚乙二醇（ＰＥＧ＿（４００）作为示踪剂，采用毛细管气相色谱技术分析４９例强直性脊柱炎（ＡＳ）、类风湿关节炎（ＲＡ）以及正常人肠道物理通透性，以探讨肠粘膜通透性在ＡＳ发病及病情活动中的作用和ＨＬＡ－Ｂ＿（２７）对肠道通透性的影响。结果表明：ＡＳ组患者除第一组份（分子量为２４２）的百分回收率高于正常组及最大回收百分比［Ｒ＿（ｍａｘ）（％）］低于正常组外，其他指标无统计学差异。结果提示ＡＳ患者肠道通透性并不增高，肠道细菌抗原的侵入并非仅仅由于肠道通透增加所致。推测肠粘膜上皮细胞对细菌抗原的某种形式的“主动转运”可能是抗原侵入的更为重要原因，有待于进一步深入研究以证实。y use of low molecular weight polyetmene glycol( PEG_(400) ) as tracer, a revisedChedwick method with capillary gas chromatography was used to examine the intestinal permeability in 49 subjects including patients with ankylosing spondylitis (AS)and rheumatoid arthritis(RA)and heaIthy controls. Recovery percentage, maximal recovery percentage[R_(max)(%)] and R_(max),(w)were used to find the effect of bowel perme-ability in the pathogenesis and disease flare up of AS, as well as the role of HLA-B_(27) for the bowel perme-ability.The resuIts showed that in AS gropp,the recovery of first component(242D) was higher and the R_(max)(%) was lower than those in the controls. No statistical difference was found with other indexes. The resuIts indicated that bowel permeability is not elevated in AS. The passage of enteral bacteria antigen into the host may not resuIt from the process of nonspecific penetration. We postulate that there may somehow baprocess of “active transportation” in the pathogenesis of AS.More studies of the process are necessary to clarify its importance in the early stage of AS.

关 键 词：强直性脊柱炎 肠道通透性 物理通透性 病因 

分 类 号：R593.230.2[医药卫生—内科学]