流行性出血热患者血浆内皮素的动态变化及其意义  

THE SIGNIFICANCE OF DYNAMIC CHANGE OF PLASMA ENDOTHEL LEVEL IN IPIDEMIC HEMORRHAGIC FEVER

作　　者：杨宝山[1] 马英骥[1] 刘成林[1] 崔莳[1] 于丹萍张振亭 杨志洁[1] 曾庆友[1] 刘桂华 朱丽芬 

机构地区：[1]哈尔滨医科大学附属第一医院传染科,哈尔滨医科大学附属第一医院同位素室,黑龙江省九三农管局中心医院,黑龙江省讷河市第一人民医院

出　　处：《中华内科杂志》1995年第6期396-399,共4页Chinese Journal of Internal Medicine

摘　　要：为探讨内皮素（ＥＴ）在流行性出血热（ＥＨＦ）发病学中的作用及其临床意义，用特异性放射免疫法测定了１２９例ＥＨＦ患者和３０例正常人血浆ＥＴ的浓度。发现ＥＨＦ患者血浆ＥＴ在发热期、低血压休克期、少尿期和移行期均明显高于对照组，少尿期达高峰，多尿晚期恢复正常；同时发现，ＥＴ与ＥＨＦ，急者血清尿调蛋白即Ｔａｍ阶Ｈｏｒｓｆａｌｌ蛋白（ＴＨＰ）和β＿２－微球蛋白均有高度正相关性，且ＥＴ水平越高，病情越重。提示ＥＴ在ＥＨＦ发病中有重要作用，动态监测ＥＴ水平有重要临床意义。ne hundred and twenty nine hospitalized cases of epidemic hemorrhagic fever (EHF) diagnosed and classified according to the protocol of prevention and treatment of this disease approved by the Ministry of HeaIth in 1987 were studied to ascertain the role of endothelin(ET) in the etiology.30 heaIthy aduIt sub jects residing in the same area served as control.Blcod samples were collected and plasma ET Ievel was measured with radioimmunoassay and its dynamic change noted.It is shown that plasma ET Ievel of the EHF patients was higher in febrile,hypotensive or shock,oliguric and transitional stages than that of con trols.However,the level returned to normal in polyuric stage. Plasma ET Ievel was also highly positively correlated with that of Tamm-Horsfall protein(THP)and β_2 microglobulin. The higher the level of plasma ET,the poorer the ontcome,It is suggested that ET plays an important role in the epidemiology of EHF and monitoring of plasma ET Ievel will be of heip not only in predicting the prognosis,but also in guiding the clinicaI therapy.

关 键 词：内皮素 流行性出血热 病因 病理 

分 类 号：R512.802[医药卫生—内科学]