心钠素联合多巴胺治疗大鼠实验性急性肾功能衰竭的研究  

A STUDY ON COMBINED TREATMENT WITH ANP AND DOPAMINE IN ACUTE RENAL FAILUREIN RATS

作　　者：陈孝文[1] 杨华彬[1] 麦伟民[1] 周伟正[1] 李达道[1] 

机构地区：[1]广东医学院附属医院

出　　处：《中华内科杂志》1995年第9期609-611,共3页Chinese Journal of Internal Medicine

基　　金：广东省高等教育局基金

摘　　要：为了解心钠素（ＡＮＰ）在逆转急性肾功能衰竭（ＡＲＦ）时的肾小球滤过率下降，我们用顺铂（ＣＰ）腹腔注射建立实验性大鼠ＡＲＦ动物模型，并用ＡＮＰ联合多巴胺（ＤＡ）、单用ＡＮＰ与单用ＤＡ作了疗效观察，治疗结果表明：ＡＮＰ联合ＤＡ组疗效最好，显著高于单用ＡＮＰ组与单用ＤＡ组。提示ＡＮＰ联合ＤＡ可有效改善ＡＲＦ的肾功能，提高肾小球滤过率，且可有效复因ＡＮＰ所致的副作用严重低血压。cute renal failure(ARF) model was made by intraperitoneal injection of cisplatin at a dosage of 10mg/kg. After the procedure, the rats were given atrial natriuretic polypeptide(ANP)and dopamine (DA)as well as ANP or DA individually. The results indicated that combined treatment with ANP and DA was more effective for improvement of renal function in ARF(increase of GFR)than individual treat-ment with either ANP or DA. Dopamine can effectively reverse the side-effect of hypotension of ANP.

关 键 词：肾功能衰竭 多巴胺 心钠素 药物疗法 大鼠 

分 类 号：R692.505[医药卫生—泌尿科学] R969.4[医药卫生—外科学]