米力农对慢性充血性心力衰竭血液动力学即刻效应的多中心临床研究  

HEMODYNAMIC EFFECTS OF MILRINONE ON PATIENTS WITH CHRONIC CONGESTIVE HEARTFAILURE:A MULTICENTER STUDY

作　　者：黄德嘉[1] 文山[1] 尹秋熙[1] 朱俊[1] 宋有城[1] 祝善梭 孟春荣 蔡有珍 智光 陈练 马慧卿 何国祥 司良仪 刘中英 蔡力 陶剑虹 莫余波 魏宗德 田军 沈潞华 韩小茜 顾复生 

机构地区：[1]华西医科大学第一附属医院,北京阜外医院,第三军医大学第二附属医院,北京解放军总医院,第三军医大学第一附属医院,四川省人民医院,沪州医学院附属医院,北京军区总医院,北京友谊医院

出　　处：《中华内科杂志》1995年第9期599-602,共4页Chinese Journal of Internal Medicine

摘　　要：采用随机双盲，安慰剂对照，自身交叉试验设计方案，观察了国产米力农对５７例慢性充血性心力衰竭的即刻血波动力学效应。用Ｓｗａｎ－Ｇａｎｚ导管法测量血液动力学指标。静脉注射米力农后，心脏指数由２．２０±０．６４增加到２．９５±０．７１Ｌ／ｍｉｎ·ｍ￣２，Ｐ＜０．０５，平均肺毛细血管楔嵌压由３．０３±０．９５降到２．０９±１．１０ｋＰａ（２２．７０±７．６４降到１５．５６±８．１３ｍｍＨｇ），Ｐ＜０．０５。安慰剂对血液动力学指标无明显影响。对慢性充血性心力衰竭，米力农具有强心和扩血管作用。n this multicenter,randomized,double-blind,cross-over,placebo-controlled trial,hemdynamic ef-fects of domestic milrinone were studied in 57 patients with functional class Ⅲ or Ⅳ chronic congestive heart failure,The baseline values of hemodynamic parameters were measured with standard method through Swan-Ganz catheter. During intravenous infusion of milrinone or placebo,the changes of hemody-namic parameters were monitored throughout the procedure,Compared with the baseline values, cardiac index increased from 2.20±0.64 to 2. 95 ± 0. 71L/min·m￣2 (P<0. 05 ) and pulmonary capillary wedge pressure fell from 22.7±7. 64 to 15. 56±8.13 mmHg(P<0.05) during intravenous infusion of milri-none, The placebo had no effects on hemodynamics in this group of patients.Milrinone has both Inotropic and vasodilative effects on patients with chronic congestive heart failure.

关 键 词：心力衰竭 充血性 血液动力学 米力农 

分 类 号：R969.1[医药卫生—药理学] R541.610.5[医药卫生—药学]