哮喘患者嗜酸粒细胞阳离子蛋白及其细胞密度的改变  被引量:9

CHANGES OF SERUM EOSINOPHIL CATION PROTEIN LEVEL AND BLOOD EOSINOPHIL DENSI-TY IN PATIENTS WITH ASTHMA

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作  者:王杭君[1] 孙滨[1] 

机构地区:[1]西安第四军医大学西京医院呼吸科

出  处:《中华内科杂志》1995年第12期802-804,共3页Chinese Journal of Internal Medicine

摘  要:为研究哮喘患者体内嗜酸性粒细胞(EC)、T淋巴细胞功能状态及相互关系,对哮喘,急者外周血EC密度及血清嗜酸细胞阳离子蛋白(ECP)、可溶性白介素-2受体(sIL-2R)浓度进行检测。结果表明,哮喘患者外周血低密度EC增多,血清ECP、sIL-2R浓度同时增高且幅度一致。提示EC的激活与T淋巴细胞激活有关,两者共同参与哮喘的发病过程。o study the functional state as well as the relatIon-ship between eosinophil and T lymphocyte in the asthmatics,the authors measured the eosinophil density of blood with percoll、the level of serum eosinophil cation protein( ECP)with radioimmunolassay and soluble IL-2 receptor(sIL-2R )concentration with FLISA. The results revealed that the proportlon of hypodense eosinophil and the levels of serum ECP and sIL-2R were 36.30%±14.80%,10.74±7.22mg/L,and 0.33%±0.10U/L respectively in asthmatics,being significantly higher than those in normal subjects(14.71%±8.20%,6.93±4 91mg/L,0.13±0。03U/L,respectively,P<0.05 in all).There is remarkable correlation between any two of the three pa-rarneters(r-0. 40,0.37,0.39,respectlvely,P<0. 05).It is suggested that eosinophil activation is asso-ciated with T lymphocyte activation,hoth may he involved in the pathogenesis of asthma.

关 键 词:哮喘 嗜酸细胞 T淋巴细胞 嗜酸粒细胞 

分 类 号:R562.250.2[医药卫生—呼吸系统]

 

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