肾移植患者血清α_1－微球蛋白和β_2－微球蛋白测定的临床价值  

The clinical value of serum α_1-microglobulin and β_2-microglobulin in renal transplatation

作　　者：郑军华[1] 闵志廉[1] 贺宗理[1] 何长民[1] 朱有华[1] 

机构地区：[1]上海第二军医大学附属长征医院肾移植中心

出　　处：《中华器官移植杂志》1995年第1期25-26,共2页Chinese Journal of Organ Transplantation

摘　　要：测定了４５例肾移植患者术后血清α１－微球蛋白（α１－ＭＧ）、β２－微球蛋白（β２－ＭＧ）的含量，结果表明，α１－ＭＧ与血清肌酐呈正相关，术后肾功能正常者α１－ＭＧ、β２－ＭＧ下降，但仍高于正常，术后排斥者及环孢素肾中毒者的α１－ＭＧ及β２－ＭＧ均明显升高。结果提示α１－ＭＧ是一项较β２－ＭＧ更为敏感的反映移植肾功能的指标。测定血清α１－ＭＧ对早期诊断肾移植后急性排斥及环孢素Ａ肾中毒具有一定的临床应用价值。We detected the serum levels of α1-microglobulin (α1-MG) and β2-microglobulin (β2-MG) in 45 cases of renal transplatation. The results showed that the serum levels of α1-MG and Creative were closely related. The levelsof α1-MG and β2-MG were decreased in the recipients with normal graft funtion, but still higher than that in the normal. They were increased significantly during the episod of acute rejection and in cyclosporing A rejection and in cyclosporing A nephro toxicity Patients. It was suspected that α1-MG was a more sensitive index reflecting graft funtion that β2-MG. The detection of serum α1-MG was of certain clinical Value on eraly diagnosis of acute rejection and Cyclosporin A nephrotoxicity in renal transplant recipients.

关 键 词：肾移植 微球蛋白 α1 β2 

分 类 号：R699.2[医药卫生—泌尿科学]