血液透析滤过的评价  

Preliminary evaluation of hemodiafiltration

作　　者：朱兰英[1] 秦曙光[1] 张振露[1] 李欣[1] 王铁丹 肖应庆 

机构地区：[1]中山医科大学附属第一医院血液净化中心,广州市第一人民医院肾内科,第一军医大学生物化学教研组

出　　处：《中华器官移植杂志》1995年第3期117-118,共2页Chinese Journal of Organ Transplantation

摘　　要：应用血液透析滤过（ＨＤＦ）对３１例尿毒症患者进行了５００次治疗，与常规血液透析（ＨＤ）比较，ＨＤＦ治疗中低血压的发生率低。ＨＤＦ组治疗后血β＿２微球蛋白、中分子物质明显下降，而ＨＤ组无此作用。ＨＤＦ对ＢＵＮ、Ｃｒ的清除率明显高于ＨＤ，其Ｋｔ／Ｖ值与ＨＤ组比较差异不显著，说明ＨＤＦ３小时可取得ＨＤ４～４．５小时的清除效果，以尿素动力学模型评价可达到充分透析。This study was undertaken to compare the clinic effect of hemodiafiltration (HDF) with that of hemodialysis (HD). 31 patients on chronic hemodialysis had been switched to HDF. A significant decrease of the frenquency of hypotension was observed during HDF. The meanplasma β_2microglobulin (β_2MG ) and middle molecular substance (MMS) levels decreased during HDF (P<0.01) . On the contrary , no significant decreases of plasma β_2MG and MMS were found during HD. HDF offered higher clearance for creatinine and urea than HD (P<0. 01). No significant difference of Kt/V values was found between HD and HDF groups. In conclusion,HDF present an advanced technique that offers the highest clearance of metabolic wastes and good vascular stability. HDF treatment for 3 hours can give adequate dialysis for high Kt/V values as well as HD treatment for 4 hours.

关 键 词：血液透析 尿毒症 血液透析滤过 尿素动力模型 

分 类 号：R459.5[医药卫生—治疗学]