血浆粘附分子GMP－140测定在肾移植中的意义  

Clinical significance of GMP-140 in renal transplantation

作　　者：邱平[1] 张仕光[1] 

机构地区：[1]广东肇庆市第一人民医院肾内科,中山医科大学肾脏研究所

出　　处：《中华器官移植杂志》1995年第3期108-110,共3页Chinese Journal of Organ Transplantation

摘　　要：随机选择６４例肾移植患者采用酶联免疫吸附法检测其血浆粘附分子ＧＭＰ－１４０水平，以探讨肾移植患者血浆ＧＭＰ－１４０水平的变化及意义。结果环孢素肾中毒组的血浆ＧＭＰ－１４０水平中度升高（２９２±９９μｇ／Ｌ），与移植肾功能稳定组比较（１１４±３０μｇ／Ｌ）差异显著（Ｐ＜０．０１）；排斥组（５１５±１８７μｇ／Ｌ）与稳定组及环孢素肾中毒组比较，差异显著（Ｐ＜０．０１）；肾功能稳定但并发感染者血浆ＧＭＰ－１４０水平（５３５±１７２μｇ／Ｌ）与急性排斥组比较差异不显著。结果提示测定血浆ＧＭＰ－１４０的变化对肾移植术后的监测具有一定的意义。The level of plasma adhesion molecule, GMP-140 were detected with ELISA method in 64 randomly selected renal graft recipients. Following results were observed: (1) The recipients with CsA nephrotoxicity showed the medium elevation of plasma GMP-140 levels(292±99μg/L) , and was significantly higher than that of the stable group;(2) Acute rejection caused most marked elevation of plasma GMP-140 levels (515±187μg/L) which was also significantly higher than that of the nephrotoxicity or stable sroup (P<0.01) ; (3)The plasma GMP-140 levels in recipients with infection were as similarly high (535±172μg/L) as the rejection group (P<0. 05); (4) Four patients with different postoperative courses showed some regularities of plasma GMP-140 chanses. It was suggested that the plasma GMP-140 monitoring might be helpfut to diagnose rejection and CsA nephrotoxicity, and to evaluate the effectof antirejection therapy.

关 键 词：血浆 GPM-140 测定 肾移植 

分 类 号：R699.2[医药卫生—泌尿科学]