微囊化新生猪胰岛样细胞团异种移植  

Transplantation of encapsulated neonatal porcine islet-like cluster cells(ICC) into rats

作　　者：陈冰[1] 刘纪宁[1] 祝希媛[1] 刘新民[1] 

机构地区：[1]北京友谊医院临床医学研究所,沈阳军区总医院内分泌科

出　　处：《中华器官移植杂志》1995年第4期152-153,共2页Chinese Journal of Organ Transplantation

摘　　要：本实验研究新生猪与大鼠间的异种移植。结果显示，新生猪胰岛样细胞团（ＩＣＣ）可纠正糖尿病大鼠的高血糖状态；海藻酸钠－多聚赖氨酸微囊能有效保护移植物的存活，平均存活时间为４个月（Ｐ＜０．０１）。而微囊作为一种新型防排斥手段。This paper reports the extensive ICC surrival by microencapsulation which indicated remarkable protection of alginate poly-L-lysine membrane in lack of immunosuppressive drugs,and the reversion of diabetic state in rats.The results suggested that the pocine was an optimal donor source for islet transplantation and the microcapsule did protect the xenograft from rejection by the recipient immune system.

关 键 词：猪胰岛 微囊 异种移植 糖尿病 胰岛移植 

分 类 号：R587.105[医药卫生—内分泌] R657.5[医药卫生—内科学]