尿毒症患者血小板膜糖蛋白Ib含量和血浆vWF浓度变化及意义  

THE SIGNIFICANCE AND CHANGE OFPLATELET MEMBRANE GLYCOPROTEIN IB ANDPLASMA VWF CONCENTRATIONS IN UREMIC PA-TIENTS

作　　者：刘平[1] 王学文[1] 杨志成[1] 季大玺[1] 姚海勤[1] 黎磊石[1] 

机构地区：[1]江西九江解放军171医院内一科,南京军区总医院血液科

出　　处：《中华肾脏病杂志》1995年第2期69-71,共3页Chinese Journal of Nephrology

摘　　要：对尿毒症患者血小板膜糖蛋白（ＧＰ）Ｉｂ含量用两种不同方法进行测定，同时测定血浆中ｖｏｎＷｉｌｌｅ－ｂｒａｎｄＦａｃｔｏｒ（ｖＷＦ）浓度。结果显示尿毒症组血小板膜ＧＰＩｂ含量显著低于对照组（Ｐ＜０．０１），血透后减少更明显（Ｐ＜０．０５），两种方法测定的血小板膜ＧＰＩｂ减少之间呈正相关（ｒ＝０．５２Ｐ＜０．０１），尿素氮升高与血小板膜ＧＰＩｂ减少无明显相关关系（ｒ＝一０．２Ｐ＞０．０５），血浆中ｖＷＦ也显著高于对照组（Ｐ＜０．０１），提示：尿毒症患者血小板功能缺陷与血小板膜ＧＰＩｂ缺乏关系密切，尿毒氮升高可能不是直接使ＧＰＩｂ减少的原因，血小板止血功能障碍使ｖＷＦ代偿性增高，血液中存在抑制ｖＷＦ与血小板结合的物质。e studied the platelet GPIb with two methods,vWF were determined in uremic patients.Our resultsshowed the platelet GPIb were decreased in uremia(P<0. 01).Post-dialysis GPIb levels were lower thanpre-dialysis. There was significant positive correlationbetween the platelet GPlb levels used two methods(r= 0. 52,P<0. ol).There was negative correlative be-tween the increment of urea nitrogen and reduction ofplatelet GPIb.The platelet dysfunction was closely re-lated to decrement of platelet GPIb in uremic patients.Platelet hemostatic dysfuntion raise plasma levels ofvWF compensatively.There were toxic metabolicproducts inhibited vWF binding to platelet in blood.

关 键 词：尿毒症 血小板膜 GPIB VWF 

分 类 号：R695.02[医药卫生—泌尿科学]