狼疮性肾炎患者血清DNA－抗－DNA免疫复合物与蛋白尿和肾脏病理类型的关系  

Relationship of DN A-anti-DNA immune complexes to proteinuria and renal histopathologic types inserum of patients with lupus nephritis

作　　者：王丹[1] 尹培达[1] 唐世聪[1] 姜傥[1] 杨岫岩[1] 

机构地区：[1]中山医科大学附一院肾脏研究所

出　　处：《中华肾脏病杂志》1995年第6期354-356,共3页Chinese Journal of Nephrology

基　　金：1994年国家高等学校博士点专项基金

摘　　要：利用单克隆抗－ＤＮＡ抗体检测了３９名狼疮性肾炎（ＬＮ）患者不同的时期内不同类型的血清ＤＮＡ－抗－ＤＮＡ免疫复合物（抗ＤＮＡＩＣ），其中２４例做了肾活检。结果显示：活动期ＬＮ患者血清抗－ＤＮＡＩＣ的类型分布与患者的肾脏病理类型有一定的关系，有助于推测ＬＮ肾组织病理类型，ＩｇＧ型的抗单链ＤＮＡＩＣ（抗－ｓｓＤＮＡ－ＩｇＧ）与２４ｈ尿蛋白定量呈正相关。进一步说明抗－ＤＮＡＩＣ在ＬＮ的发病机理中有较重要的作用。erum DNA-anti-DNA immune complexes (anti-DNA IC)in different stages of 39 patients with lu-pus nephritis(LN)were measured by two-antibodies sandwich ELIsA technique using mice anti-DNAmonoclonal antibody. 24 patients had received renal biopsy,The results showed that there was a certainretolationship of distribution of serum anti-DNA IC type in patients with LN in active stage to renalhistopathologic types,It was benificial to estimate the renal histopathological types of LN. Serum anti-ssDNA-IgG showed positive correlation with 24 hours guantitative proteinuria. It further suggested thatanti-DNA IC played a more important role in pathogenic machanism of LN.

关 键 词：狼疮性肾炎 蛋白尿 免疫复合物 血清 病理 

分 类 号：R593.242[医药卫生—内科学]