乙型肝炎基因工程疫苗阻断乙型肝炎病毒母婴传播的研究  

Interruption of Perinatal Transmission of Hepatitis B Virus with a Recombinant Vaccine Prepared from Transgenic Chinese Hamster ovary Cell Line

作　　者：王树声[1] 李艳萍[1] 李荣成[1] 杨进业[1] 陈琨琳 任贵方[1] 黎国形[1] 陈红[1] 王文[1] 叶世德[1] 张兴义[1] 张权一[1] 

机构地区：[1]广西壮族自治区卫生防疫站,中国预防医学科学院病毒学研究所,卫生部长春生物制品研究所

出　　处：《中华实验和临床病毒学杂志》1995年第2期132-134,共3页Chinese Journal of Experimental and Clinical Virology

摘　　要：用转基因细胞（ＣＨＯ－Ｃ２８）分泌的乙型肝炎病毒表面抗原基因工程疫苗免疫母亲ＨＢｓＡｇ阳性的新生儿５０例，观察其阻断乙型肝炎病毒母婴传播的效果，随访１２个月，在３６例母亲为ＨＢｓＡｇ和ＨＢｅＡｇ均阳性的婴儿中仅１例为ＨＢｓＡｇ阳性，其余婴儿均有保护性抗体，预防保护率为９６．２％。１４例母亲单独ＨＢｓＡｇ阳性的所有婴儿抗ＨＢｓ均阳转，保护率达１００％。抗ＨＢｓ阳性的婴儿均具有较高抗体水平，抗ＨＢｓＧＭＴ为１１．１５６×１０５～１３．１３４×１０５ｍＩＵ／Ｌ。说明ＣＨＯ乙型肝炎基因工程疫苗具有较好的免疫原性和近期保护效果。This paper reports the efficacy of blockage of perinatial transmission of HBV in 50 neonates born to HBsAg carrier mothers with 20mg/L of a recombinant vaccine prepared from transgenic Chinese hamster ovary cell line (CHO) C28, following a 0, 1, 6 months schedule. One out of 36 neonates whose mother’s both HBsAg and HBeAg positive was positive for HBsAg and the anti-HBs conversion rate was 91.6%, the protective rate being 96.2% at 12 months after first dose. All of the 14 neonates whose mother’s were being HBsAg positive developed anti-HBs and none of them became HBsAg positive. The geometric mean titres (GMT) of their anti-HBs were 11.155×105-13.134×105mIU/L. The results indicate that the immunogenicity and protechve rate of the HBV recombinant vaccine appears to be valid in blocking of perinatal transmission of HBV.

关 键 词：基因工程疫苗 母婴传播 病毒传播 乙型肝炎 

分 类 号：R512.620.3[医药卫生—内科学]