当前流行的乙型流感病毒血凝素蛋白的抗原性及其基因特性  

Studies on Antigenic and Genetic Characterization of the Haemag lutinins of Recent Circulating Strains of Influenza B Virus

作　　者：王敏[1] 郭元吉[1] 徐西雁[1] 舒跃龙[1] 

机构地区：[1]中国预防医学科学院病毒学研究所,美国疾病控制中心

出　　处：《中华实验和临床病毒学杂志》1995年第3期258-261,共4页Chinese Journal of Experimental and Clinical Virology

摘　　要：通过抗原性分析弄清了近年来连续２次乙型流感病毒在我国人群中造成流感流行，是由于乙型流感病毒株发生抗原性变异所造成。通过毒粒基因分析发现，我国人群中流行的Ｂ／Ｐａｎａｍａ／４５／９０类毒株，其ＨＡＩ区氨基酸序列比国际代表性毒株Ｂ／Ｐａｎａｍａ／４５／９０病毒在１６５位点上多一个氨基酸（天冬酰胺），乙型流感病毒流行株可能具有地区性差异。Through the antigenic analysis. the reason of two influenza epidemics associated with influenza B virus in human population in China during the 1992-1993 and 1993-1994 was revealed.That was due to the occurrence of antigenic drift of influenza B virus.The genetic analysis indicated than the length of amino acid of HAI domain of B / Panama / 45 / 90 like virus isolated in China was one amino acid longer than that of B / Panama / 45 / 90 virus,e.g. an amino acid (asparagine)was inserted into 165 position of HAI domain of Chinese strains. This finding had been further demonstrated (unpublished data) and pointed out that influenza B viruses,unlike influenza A viruses, migth be of significant difference in viral location in genetic characteristics of viruese.

关 键 词：乙型流感病毒 流行性感冒 血凝素 抗原 基因 

分 类 号：R511.7[医药卫生—内科学] R373.13[医药卫生—临床医学]